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Ankylosing Spondylitis Clinical Trials

A listing of Ankylosing Spondylitis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (11) clinical trials

Pilot Open Label Clinical Trial With Abatacept in Ankylosing Spondylitis

Clinical manifestations and prevalence of ankylosing spondylitisAnkylosing spondylitis (AS) is a chronic inflammatory disease which affects primarily the spine and the sacroiliac joints, but extraspinal structures such as peripheral joints, the enthesis (insertion of tendons/ligaments at bone), the eye (uveitis) and the aorta can also be involved. There is a ...

Phase

Examination of Radiographic Progression Efficacy and Safety of Long-Term Treatment With Infliximab in Patients With Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown etiology that involves the sacroiliac joints, axial skeleton, entheses and peripheral joints. Chronic inflammation of entheses leads to new bone formation, syndesmophytes and ankylosis of joints, primarily in the axial skeleton. This leads to a dramatic loss of range of ...

Phase N/A

Prednisolone in Active Ankylosing Spondylitis (AS)

Treatment of inflammatory rheumatic conditions with glucocorticosteroids is a mainstay in therapy. In rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematodes and polymyalgia rheumatica glucocorticosteroids show a prompt effect in regards of musculoskeletal symptoms. Ankylosing spondylitis (AS) is an inflammatory rheumatic disease mainly affecting the spine. However peripheral joints, ...

Phase

A Study to Assess Efficacy and Safety of Filgotinib in Ankylosing Spondylitis

This is a multicenter, Phase 2, double-blind, placebo-controlled study in subjects with active Ankylosing Spondylitis (AS). A total of approximately 100 subjects will be randomized to one of 2 treatment arms in a 1:1 ratio: oral filgotinib tablets q.d. or matching placebo q.d. Treatment duration will be 12 weeks. Each ...

Phase

Study of Efficacy and Safety of Secukinumab in Patients With Ankylosing Spondylitis

To demonstrate the clinical efficacy, safety and tolerability of secukinumab compared to placebo in patients with ankylosing spondylitis at Week 16 and long term efficacy and safety up to Week 52.

Phase

Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases

Protocol: TRANSREG is a multicentric, uncontrolled, open-label study, comparing biological and clinical responses to the administration of low doses IL2 across 12 selected pathologies: rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, psoriasis, Behcet's disease, Wegener's granulomatosis, Takayasu's disease, Crohn's disease, ulcerative colitis, autoimmune hepatitis, sclerosing cholangitis and Gougerot-sjögren. Methods: Each ...

Phase

99mTc-rhAnnexin V-128 a Phase I/IIa Study in Patients With Rheumatoid Arthritis (RA) or Ankylosing Spondylitis (AS)

The objectives of the study are: Primary objective: - To determine the safety and tolerability of medical imaging with 99mTc-rhAnnexin V-128 Secondary objectives: - To determine the biodistribution, pharmacokinetics and radiation dosimetry of 99mTc-rhAnnexin V-128 - To demonstrate the time-dependant distribution and localization of 99mTc-rhAnnexin V-128 both in RA and ...

Phase

Etanercept Withdrawal And Retreament Study In Subjects With Nr-ax SpA

This multcenter, open-label, three period study will evaluate withdrawal and retreatment of etanercept in subjects with nr-ax SpA who achieved adequate response following 24 weeks of treatment.

Phase

Adalimumab in Alleviating Inflammation in Patients With Axial Spondyloarthritis

Axial spondyloarthritis is an inflammatory rheumatic disease mainly affecting joints in the spine and the sacroiliac joints. Inflammatory pathways are likely the central link from axial spondyloarthritis to the known increased risk of atherosclerotic morbidity. Positron emission tomography (PET) is the most sensitive method to detect inflammatory foci in clinical ...

Phase

A Multicentre Study to Evaluate the Efficacy and Safety of ENIA11 in Patients With Ankylosing Spondylitis

This is a multi-center, double-blind, randomized, parallel-group, placebo-controlled study to evaluate the efficacy and safety of ENIA11 in patients with ankylosing spondylitis. The study period for each patient will be 27 weeks, during which the patient will undergo screening for up to 21 days, and followed by treatment of 24 ...

Phase