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Hemorrhage Clinical Trials

A listing of Hemorrhage medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (45) clinical trials

Tranexamic Acid to Reduce Blood Loss in Hemorrhagic Caesarean Delivery

Postpartum hemorrhage (PPH) is the leading cause of maternal death. Tranexamic acid (TA) (Exacyl Sanofi France), an antifibrinolytic drug, reduces bleeding and transfusion need in major surgery and trauma (1). In ongoing PPH following vaginal delivery (2), a high dose of TA decreased the volume and duration of PPH, the ...

Phase

Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study

To date, no novel or pharmacologic methods of reducing blood loss have been described for women at risk for placenta accreta. Intravenous tranexamic acid (TXA), a drug with anti-fibrinolytic activity, is routinely used in elective orthopedic and cardiac surgery to reduce blood loss. Intravenous tranexamic acid is currently FDA approved ...

Phase

Prevention of Postpartum Hemorrhage With TXA

Hemorrhage remains the leading cause of maternal mortality worldwide. In a 2014 systematic analysis of the causes of maternal death, the World Health Organization (WHO) noted that even in the face of interventions developed to actively manage the third stage of labor, 27.1% of maternal deaths were directly attributable to ...

Phase

Comparision Between Activated Partial Thromboplastin Time Versus Anti-Xa Activity in Heparin Monitoring

Aim of the study Based on available data, a randomized trial aimed at comparing the efficacy and safety of monitoring UFH treatments using aPTT and anti-FXa activity in patients treated with fulldoses of UFH could validly be carried out. Study design Primary objectives: safety and efficacy Secondary objectives: efficiency and ...

Phase

Bloodtranfusions After Aortic Surgery

Cardiothoracic surgery (CTC) is associated with blood loss and an increased risk for impaired coagulation by the use of a CBP. Coagulation is a process of primary hemostasis by adhesion of trombocytes and aggregation, followed by secondary coagulation and fibrin formation. During CTC fibrinogen is the first coagulation factor which ...

Phase

The Effect of Topical Tranexamic Acid on Bleeding and Seroma Formation in After Undergoing Mastectomy

After surgical procedures, interventions to reduce postoperative bleeding are of great importance. In this study, the effect will be investigated of smearing tranexamic acid, which is designed for injection, directly onto the raw wound surface (topical application) created during surgery. Topical application allows a small amount of drug to reach ...

Phase

Carbetocin Versus Misoprostol in High Risk Patients for Postpartum Hemorrhage After C.S.

Postpartum hemorrhage was traditionally defined as blood loss in excess of 500 mL from a vaginal delivery or 1000 mL at cesarean section. It can result from uterine atony, retained placental tissue including that from abnormal placentation, maternal genital tract trauma and coagulopathies. (Almog et al, 2011) Uterotonic agents (e.g. ...

Phase

Aromatase Plus GnRH Analogue Versus Ulippristal Acetate in Uterine Fibroids

Recently it has been introduced the Ulipristal acetate as medical treatment for symptomatic uterine fibroid. The investigators used in the past for the treatment of other benign gynecological diseases such as endometriosis and adenomyosis a combined therapy with Aromatase inhibitor plus GnRH analog. The investigators also used this combined treatment ...

Phase

Safety and Efficacy of Oral TXA in Reducing Blood Loss and Transfusion in Hip Fractures

Hip fractures are associated with significant blood loss and a subsequent need for blood transfusion. The causes of bleeding are multifactorial, increased fibrinolytic activity being one of them. The use of allogenic blood products is expensive and is associated with increased risk of hemolytic and anaphylactic reactions, post-operative infections and ...

Phase

The Paediatric EVICEL Soft Tissue and Parenchymal Organ Bleeding Study

This is a prospective, randomized, controlled, clinical study comparing EVICEL to SURGICEL, as an adjunct to haemostasis when conventional methods of controlling bleeding are ineffective or impractical during surgery in paediatric patients. At least 40 qualified paediatric subjects with an appropriate mild or moderate Target Bleeding Site (TBS) will be ...

Phase