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Depression (Treatment-Resistant) Clinical Trials

A listing of Depression (Treatment-Resistant) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (30) clinical trials

Implementation Trial of Evidence Based Practices for Mood Disorders

The objective of this Implementation Trial is to evaluate the implementation of evidence based practices for Bipolar Disorder and Treatment Resistant Depression in small rural Federally Qualified Health Centers. The evidence based practices were chosen and adapted by Health Center providers and patients in consultation with clinical experts. The evidence ...

Phase N/A

Ketamine for Treatment Resistant Late-Life Depression

Primary Aim: To identify and evaluate the durability of benefit of the best performing of 3 sub-anesthetic doses of a single ketamine (0.1 mg/kg, 0.25 mg/kg, and 0.50 mg/kg) and midazolam (MID) (0.03 mg/kg) infusion in up to 72 Veterans with Late-Life Treatment Resistant Depression (LL-TRD). Hypothesis 1: the durability ...

Phase

Deep Brain Stimulation for Treatment Resistant Depression

Major Depression is one of the most common and costly of all psychiatric disorders. While depression can be effectively treated in the majority of patients by either medication or some form of evidence-based psychotherapy, up to 20% of patients fail to respond to standard interventions. For these patients, trial-and-error combinations ...

Phase

A Double-Blind Sham Controlled Trial of rTMS in Treatment Resistant Major Depression

Justification for project TRD is clearly a major health issue - depression is common, results in marked morbidity and mortality and a large percentage of patients do not respond to, or cannot tolerate standard treatment. The development of new treatments for this condition is undoubtedly required. International efforts are underway ...

Phase N/A

Treatment Resistant Depression and Obstructive Sleep Apnea Effect of Continuous Positive Airway Pressure (CPAP)

Primary objective: What is the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD and associated OSA? Secondary objectives: 1. How common is co-morbid OSA in patients with treatment resistant unipolar depression referred to a tertiary Mood Disorders Clinic? 2. Is there ...

Phase N/A

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

The purpose of this study is to characterize the PK ( Pharmacokinetics) of understudied drugs administered to children per standard of care as prescribed by their treating caregiver. This will be accomplished by the collection of biological samples during the time of drug administration per standard of care as prescribed ...

Phase N/A