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Depression (Treatment-Resistant) Clinical Trials

A listing of Depression (Treatment-Resistant) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (70) clinical trials

This is a Phase 3b multicenter study of adjunctive ALKS 5461 2/2 that will utilize a randomized, double-blind, 2-stage, placebo-controlled, sequential parallel comparison design (SPCD). The purpose of this study is to evaluate the efficacy, safety, and tolerability of adjunctive ALKS 5461 2/2 (2 mg buprenorphine [BUP]/2 mg samidorphan [SAM]) ...

Phase

The primary purpose of this research study is to determine if the investigational medication, rapastinel, is effective versus placebo in the treatment of major depressive disorder. (A placebo looks the same as the study drug but has no active ingredients in it).    After an initial up to 14 day screening ...

Phase

To evaluate the efficacy and safety of AXS-05 relative to bupropion in subjects with treatment resistant major depressive disorder (MDD). This is a randomized, double-blind, active-controlled, 12-week, two-period study consisting of an open-label, bupropion lead-in period, and a double-blind treatment period. The trial is being conducted in subjects with treatment ...

Phase N/A

This is a study of brexpiprazole or placebo in combination with intranasal ketamine added to current antidepressant. The study lasts for 28 days and requires a total of 12 visits to the study site.

Phase N/A

Montefiore Medical Center is seeking patients with major depressive disorder (MDD) between the ages of 18 and 65 to participate in a new depression research study. Dr. Jonathan Alpert is conducting this research to assess if the combination of brexpiprazole and intranasal ketamine can safely and effectively treat depression symptoms ...

Phase

Still feeling symptoms of depression after having taken a prescription antidepressant? If so, participating in our medical research study of an investigational drug may be an option for you.

Phase

Treatment Resistant Depression and Obstructive Sleep Apnea Effect of Continuous Positive Airway Pressure (CPAP)

Primary objective: What is the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD and associated OSA? Secondary objectives: How common is co-morbid OSA in patients with treatment resistant unipolar depression referred to a tertiary Mood Disorders Clinic? Is there a difference ...

Phase N/A

Selenium as Augmentation Treatment for Sertraline Resistant Major Depression

This research aims to verify in a pilot study the effect of selenium as an augmentation treatment for sertraline-resistant major depression and, as secondary endpoints, if the levels of selenium in patients with depressive episodes are different from individuals without depression. Thus, this clinical trial was intended to be a ...

Phase N/A

Magnetic Seizure Therapy (MST) for Treatment Resistant Depression Schizophrenia and Obsessive Compulsive Disorder

Although ECT is effective against severe depression, psychosis, and OCD, it also produces significant impairments of autobiographical memory and other cognitive functions. These side effects limit the acceptability and tolerability of ECT in many patient populations. They also limit the number of treatments that can be administered in a course ...

Phase N/A

ECT With Ketamine Anesthesia vs High Intensity Ketamine With ECT Rescue for Treatment-Resistant Depression

Major depressive disorder (MDD) is a common psychiatric illness that will affect at least 15% of the population. The burden of MDD is staggering, considered by the World Health Organization to be the leading cause of disability in developed countries for people aged 15-44. Oral antidepressant therapy for MDD is ...

Phase