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Depression (Treatment-Resistant) Clinical Trials

A listing of Depression (Treatment-Resistant) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (42) clinical trials

This study will evaluate the efficacy, safety, and tolerability of rapastinel 450 milligrams (mg) compared to placebo adjunctive to antidepressant therapy (ADT) in patients with major depressive disorder (MDD) who have a partial response to ADT.

Phase N/A

Assess the Efficacy and Safety of AXS-05 Administered Orally to Subjects with Treatment Resistant Major Depressive Disorder

Phase N/A

California Neuroscience Research is conducting a research study to evaluate an investigational medication in persons with treatment resistant Major Depressive Disorder. Study Description A Randomized, Double-blind, Active- controlled Trial to Assess the Efficacy and Safety of Administered Orally to Subjects with Treatment Resistant Major Depressive Disorder.

Phase N/A

The purpose of the research study is to determine if nitrous oxide is an effective treatment for treatment-resistant bipolar depression. Participation includes 17 study visits. There will be randomization to inhalation of nitrous oxide gas or placebo, questionnaires, and blood and urine tests. Up to $320 is provided.visit. Risks and ...

Phase N/A

A randomized, double-blind, active-controlled, multicenter study in male and female adult subjects with TRD to assess the efficacy, safety, and tolerability of flexibly dosed intranasal esketamine plus a newly initiated oral antidepressant compared with a newly initiated oral antidepressant plus intranasal placebo

Phase N/A

This is a study of subjects with TRD to assess the efficacy, safety, and tolerability of intranasal esketamine plus an oral antidepressant compared to an oral antidepressant (active comparator) plus intranasal placebo.

Phase N/A

Schuster Medical Research Institute is currently seeking volunteers to participate in a research study investigating TREATMENT RESISTANT DEPRESSION. Patient Inclusion Criteria: 18-65 years of age Have a history of depression and have not responded to TWO antidepressant medications for the current episode of depression In good physical health Qualified participants ...

Phase N/A

To evaluate the efficacy and safety of AXS-05 relative to bupropion in subjects with treatment resistant major depressive disorder (MDD). This is a randomized, double-blind, active-controlled, 12-week, two-period study consisting of an open-label, bupropion lead-in period, and a double-blind treatment period. The trial is being conducted in subjects with treatment ...

Phase N/A

This is a study of brexpiprazole or placebo in combination with intranasal ketamine added to current antidepressant. The study lasts for 28 days and requires a total of 12 visits to the study site.

Phase N/A

Treatment Resistant Depression and Obstructive Sleep Apnea Effect of Continuous Positive Airway Pressure (CPAP)

Primary objective: What is the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD and associated OSA? Secondary objectives: How common is co-morbid OSA in patients with treatment resistant unipolar depression referred to a tertiary Mood Disorders Clinic? Is there a difference ...

Phase N/A