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Chronic Pain Clinical Trials

A listing of Chronic Pain medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (29) clinical trials

Genetic Determinants of Amitriptyline Efficiency for Pain Treatment - Part II

Background Pain is defined as an ongoing unpleasant sensory experience, which can be classified according to three major, although overlapping, etiologies: nociceptive, inflammatory and neuropathic pain. Antidepressants are widely used as co-analgesics in the management of chronic pain. An overview of different substances and their relation to their mechanism of ...

Phase

Genetic Determinants of Amitriptyline Efficiency for Pain Treatment

Background Pain is defined as an ongoing unpleasant sensory experience, which can be classified according to three major, although overlapping, etiologies: nociceptive, inflammatory and neuropathic pain. Antidepressants are widely used as co-analgesics in the management of chronic pain. An overview of different substances and their relation to their mechanism of ...

Phase

Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain

Methodology /Technical Approach: Seventeen patients who are already using SynchroMed II pump containing an admixture of bupivacaine and an opioid and using PTM doses will receive Solution A during the first week of the study and will be crossed over to Solution B during the second week of the study. ...

Phase

Effect of Intrathecal Morphine on Chronic Pain After Elective Caesarean Section

This prospective, randomised, double-blind trial will take place at B.P Koirala Institute of Health Sciences, a University hospital situated in Nepal. Approval for the study has been obtained from the institution ethical committee. After the trial is registered, recruitment of the patient will be initiated. Consent for the participation in ...

Phase

Effect of Combined Morphine and Duloxetine on Chronic Pain

A double-blind, randomized, and placebo-controlled clinical study examining whether duloxetine, a serotonin and norepinephrine reuptake inhibitor (SNRI), could enhance opioid analgesia and reduce overall opioid use. Positive outcomes will help improve the overall effectiveness of clinical opioid therapy and reduce unnecessary opioid dose escalation.

Phase

Anesthesia for Pain After Ankle Fracture Surgery

This pilot study will test the hypothesis that prolonged regional peripheral nerve block will reduce development of chronic pain in patients undergoing surgery for ankle fracture. Regional nerve block using local anesthetics delivered by ambulatory pump is used in some types of surgeries but is not routine for ankle fracture ...

Phase

Suvorexant in Insomnia Co-morbid With Fibromyalgia

It has now become clear that the relation of sleep and pain is bidirectional; acute and chronic pain is associated with disturbed sleep and disturbed sleep enhances pain. Experimental studies have shown that reduced and fragmented sleep in pain-free normals increases their pain sensitivity and daily self-report studies in chronic ...

Phase

Chronic Pain Risk Associated With Menstrual Period Pain

Endometrial shedding during the menstrual cycle elicits profound changes in neuronal activity and cytokines producing moderate to severe pelvic pain in more than 20% of reproductive-age women. One out of every five of those women in turn will develop chronic pelvic pain (CPP), yet women without dysmenorrhea rarely report CPP. ...

Phase

High-Volume Image-Guided Injection in Chronic Midportion Achilles Tendinopathy

Background of the study - Overuse injury of the Achilles tendon is a common entity in athletes. Especially middle aged athletes are at risk. Elite running athletes have a lifetime risk of sustaining an Achilles tendon injury of 52%. At the moment the usual treatment for chronic midportion Achilles tendinopathy ...

Phase

Placebo In Chronic Back Pain (Phase 2)

Visit 1 (week -3): Screening visit (90 min): Participants will be evaluated with inclusion/exclusion criteria and complete the informed consent documents. A medical/pain history will be taken and physical exam will be completed by a physician and participants will be asked to rate their current back pain intensity. Participants will ...

Phase