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COPD (Chronic Obstructive Pulmonary Disease) Clinical Trials

A listing of COPD (Chronic Obstructive Pulmonary Disease) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (166) clinical trials

HIV+ Alveolar Macrophage Oxidant-mediated Apoptosis of Pulmonary Endothelium

The purpose of this study is to analyze biologic samples from the blood, airways and/or urine of HIV- and HIV+ smokers and non-smokers to better understand the etiology and pathogenesis of emphysema in association with HIV infection. The underlying hypothesis is that the combination of HIV infection and smoking creates ...

Phase N/A

Integrative-omics of the Disordered COPD Small Airway Epithelium

Hypothesis: We hypothesize that the disordered differentiation of the SAE that characterizes COPD results from the complex interaction of cigarette smoke components with a hierarchy of genetic, epigenetic, gene expression and metabolomics network interactions as the BC differentiate into a mucociliary epithelium. Specific aim 1. Using an integrated network systems ...

Phase N/A

Evaluation of Novel Lung Function Parameters and Quantitative Computed Tomography (qCT) in Patients With Pulmonary Disease

Current diagnostic tools used in pulmonary disease often do not meet the challenges set by the respective pathophysiology. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of patients with various pulmonary diseases.

Phase N/A

HIV-related Accelerated Aging of the Airway Epithelium

While the epidemiologic data linking HIV infection to an increased risk for COPD is clear, the pathogenesis of the accelerated development of COPD in HIV infected smokers is not understood. We have focused on the SAE as the central target for the accelerated development of COPD in HIV infected smokers, ...

Phase N/A

Evaluation of Novel Lung Function Parameters in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of COPD.

Phase N/A

Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD

Changes within the small airways of the lungs represent the key element in the mechanism of COPD, as they precede the development of emphysema and contribute to the progressive decline in expiratory airflow. One of the key features of COPD is the remodeling of the small airway epithelium (SAE), and ...

Phase N/A

Right Heart Dysfunction and Pulmonary Hypertension Evaluation in Airway Disease Using Cardiac Magnetic Resonance

Background and Importance: Chronic respiratory diseases, which include asthma, COPD and pulmonary hypertension (PH), were responsible for 4.2 million deaths globally in 2008. COPD and asthma affect more than 500 million people worldwide and present an enormous health and economic burden. Exacerbations of airway disease contribute to disease progression and ...

Phase N/A

Examining Vascular Outcomes in COPD Inpatients (AIM 1) Examining Early Rehabilitation on Discharged COPD Patients (AIM 2)

AIM 1: Purpose: To examine pulmonary and cardiovascular outcomes in COPD patients from the time of their acute hospital admission until discharge. Rationale: AECOPD is associated with systemic inflammation, prolonged bed-rest and increased CV risk. Proper medical management strategies such as appropriate systemic corticosteroids, mobilization, and bedside education may reduce ...

Phase N/A

COPD Metabolome Smoking Oxidants and Aberrant Ciliated Cell Function

Cigarette smoking is the major cause of chronic obstructive pulmonary disease (COPD), the 4th cause of mortality in the US. Central to COPD pathogenesis is "ciliopathy", dysfunction of the airway ciliated cells that mediate transport of mucus to remove inhaled pathogens. The COPD ciliopathy leads to mucus accumulation, impaired host ...

Phase N/A

COPD Readmissions Prediction- ReCOPD Project

DESIGN: A prospective observational cohort study with a nested case control study, with one year follow-up from index hospital admission. SETTING: Multicenter and multidisciplinary study taking part the following hospitals: Costa del Sol Hospital (Andalusia), Nuestra Seora de la Candelaria University Hospital (Canary Islands), Gregorio Maran General University Hospital (Madrid), ...

Phase N/A