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Acute Respiratory Distress Syndrome (ARDS) Clinical Trials

A listing of Acute Respiratory Distress Syndrome (ARDS) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (90) clinical trials

Comparison of 2 Strategies of Adjustment of Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome

Most patients suffering from acute lung injury or acute respiratory distress syndrome require mechanical ventilation. In this setting, positive end-expiratory pressure is used to improve arterial oxygenation. While the beneficial effect on clinical outcome of using low tidal volume is clearly proven, the best way to titrate PEEP is not ...

Phase N/A

A Comparison of Optimal PEEP Determination Guided by EIT and G5 Device in Moderate and Severe ARDS Patients

To titrate PEEP guided by EIT. A global inhomogeneity (GI) index and regional compliance based on EIT were developed to quantify the tidal volume distribution within the lung. The aim of this study was to test the feasibility of optimizing PEEP with respect to ventilation homogeneity using the GI index ...

Phase N/A

Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome

Major patient-ventilator asynchronies have been described during assisted mechanical ventilation in different settings. Few studies have evaluated double cycling in ARDS patient. No clear predictors of this finding beside low tidal volume have been found, and clinical outcome implications have not been addressed. This study has 3 main objectives: evaluate ...

Phase N/A

Open Lung Strategy Gas Distribution and Right Heart Function in ARDS Patients

A recent large observational study published on JAMA showed that Acute Respiratory Distress Syndrome (ARDS) is associated with high mortality and developed in 10.4% of 29,144 patients admitted to the intensive care unit from 50 countries across 5 continents. Mechanical ventilation is the cornerstone for lung treatment during ARDS. Lung ...

Phase N/A

Practice of Ventilation in Middle-Income Countries

Rationale: scarce information exists on management of mechanical ventilation in intensive care unit (ICU) patients in low- and middle-income countries. Objective:The primary objective is to describe and compare ventilation management in patients at risk of ARDS versus individuals not at risk, and patients with established ARDS, and to ascertain whether ...

Phase N/A

Ventilation's Parameters Applied in Emergency Medicine. A Prospective Observational Study

To prospectively assess the mechanical ventilation management when its provided by Emergency Physicians in French Hospital, and to assess complications and outcome of these patients. The study could be measure the proportion of patients developing an Acute Respiratory Failure Distress after a take care of by French Emergency Departments.

Phase N/A

Pilot RCT of Therapeutic Hypothermia in ARDS Patients Receiving Neuromuscular Blockade

Background Despite recent advances in supportive care for patients with acute respiratory distress syndrome (ARDS), mortality remains >40%. Fever worsens and hypothermia mitigates animal models of ALI. A small non-randomized controlled trial of therapeutic hypothermia (TH) in moribund patients with septic shock and ARDS showed improved survival (3 of 9 ...

Phase N/A

Enhanced Lung Protective Ventilation With ECCO2R During ARDS

Acute Respiratory Distress Syndrome (ARDS) is associated with a mortality rate of 30 - 45 % and required invasive mechanical ventilation (MV) in almost 85 % of patients[1]. During controlled MV, driving pressure (i.e., the difference between end-inspiratory and end-expiratory airway pressure) depends of both tidal volume and respiratory system ...

Phase N/A

Alveolar Recruitment Maneuvers Intracerebral Hemodynamic and Oxygenation

Two ARM are compared in this study: The eSigh or extended sigh with increase of PEEP for 10 minutes to maintain plateau pressure at 40 cmH2O. During ARM, the peak pressure is limited to 50 cm H2O with decrease of tidal volume (Vt) if necessary. The continuous positive airway pressure, ...

Phase N/A

Identifying PARDS Endotypes

Enrolled subjects will have nasal and bronchial brushings collected at days 1, 4, 7, and 14 of intubation with collection of serum at these same time points. Brushing RNA will be processed by microarray for gene expression analysis and compared to previously published serum biomarkers (interleukin-8, advanced glycosylation end-product specific ...

Phase N/A