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Headaches Clinical Trials

A listing of Headaches medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (228) clinical trials

Optimized tDCS for the Treatment of Migraine

A crossover trial to establish an optimized tDCS protocol will be accomplished. Anodal and cathodal tDCS will be applied over the primary motor cortex (C3 - active and contralateral supra-orbital region - reference) and visual cortex (Oz - active and Cz - reference). Dual tDCS (anodal and cathodal - optimized ...


Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches

The foramen ovale, a kind of physiologic channel in the interatrial septum in the heart at embryonic stage, is closed normally at 5-7 months after birth. When it is not closed, it is referred to as the patent foramen ovale (PFO), which is found in approximately 1/4 of general population. ...


The Effect of Botulinum Toxin A on Headache Attributed to TMD

Temporomandibular Disorders (TMD) is a collective term, embracing a number of clinical problems that involve the masticatory muscles, the temporomandibular joint (TMJ) and the associated structures. The prime manifestation consists of pain of a persistent, recurring, or chronic nature . Pain-related TMD can affect the individual's daily activities, psychosocial functioning, ...

Phase N/A

Evaluation of Use of Brain Activity Monitoring for Prediction of Migraine Attacks

The study will be conducted in one are. Participants diagnosed with migraine, will be evaluated for their EEG characteristics as well as daily migraine related clinical and general status. Participants' monitoring will be conducted for 20 times for a duration of one month.

Phase N/A

Continuous Positive Airway Pressure as a Potential New Treatment for Cluster Headache

This is a single center study carried out in collaboration between the neurological, neurophysiological and thoracic departments at St. Olavs Hospital in Trondheim. Participants will keep sleep and headache diaries in a baseline period of 4 weeks, then receive treatment (CPAP or sham-CPAP at nighttime) during 8 weeks, have a ...

Phase N/A

Bronx MBCT-Migraine

This randomized clinical trial aims to examine the effect of a standardized 8-week course of Mindfulness Based Cognitive Therapy for Migraine on migraine-related disability in people with migraine.

Phase N/A

Cognitive Effects of Immediate Release Topiramate vs Extended Release Topiramate in Patients With Migraine

The primary objective is to compare the effect of treatment with an immediate-release topiramate (IR-TPM), namely Topamax, to an extended-release topiramate (XR-TPM), namely Trokendi XR, regimen on cognition in adults with migraine. The secondary objective is to determine the factors that explain inter-individual variability in cognitive response. Pharmacokinetic and demographic ...


Prazosin for Post-Concussive Headaches

Background and Rationale: Headaches following mild traumatic brain injury (mTBI) are common, can be refractory to standard therapies, and may persist and worsen to become a debilitating chronic pain syndrome. The purpose of this study is to evaluate the centrally acting alpha-1 adrenoreceptor (AR) antagonist drug prazosin as a prophylactic ...


Effect of Transmagnetic Stimulation on Conditioned Pain Modulation (CPM)

rTMS of different intensities, frequencies and location will be applied during CPM to evaluate the central mechanisms of pain modulation, their location and role in pain reduction through enhancement or suppression of activity in the relevant brain regions. In other words, cortical regions that may be implicated in CPM will ...

Phase N/A

Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraphic Study

The aim is to investigate circadian rhythm in episodic cluster headache patients in- and outside of bout. This will be done using actigraphy and a short diary for 2 weeks in each period. A secondary outcome is to look at attack occurence and physical activity before and during an attack.

Phase N/A