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Rectal Cancer Clinical Trials

A listing of Rectal Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (215) clinical trials

Cancer is the second-leading cause of death in the United States today. The majority of cancer deaths can be attributed to the metastatic spread of solid tumors to distant organs. Medical progress in the last century has aided in the earlier identification of cancers limited to the primary organ and ...

Phase N/A

This study is being done to compare two types of surgery currently used for rectal cancer. The two types of surgery are laparoscopic-assisted rectal resection and open laparotomy rectal resection. Although laparoscopic-assisted rectal resection is being used for rectal cancer in some medical centers, there are still questions about whether ...

Phase

Wound infections can occur in about 12-25% of patients undergoing colorectal surgery despite routine efforts to prevent them. This study is being done to assess the safety and ability of an experimental drug called E-101 Solution (study drug), in addition to routine efforts, to prevent incisional wound infection for 30 ...

Phase

The ROLARR study is for participants with cancer of the rectum for whom a laparoscopic operation (sometimes called “keyhole surgery”) has been recommended by their surgeon. There is now another option to remove rectal cancers which involves using a robotic system with keyhole surgery. This type of surgery is called ...

Phase N/A

You are being asked to take part in this research study because you have cancer of the rectum. The standard treatment for locally advanced rectal cancer involves chemotherapy and radiation, known as 5FUCMT, (the chemotherapy drugs 5-fluorouracil/capecitabine and radiation therapy) prior to surgery. Although radiation therapy to the pelvis has ...

Phase N/A

LifeSeal™ Kit, surgical sealant designed for staple-line reinforcement that is applied over the anastomotic line to prevent bowel content leakage until full physiological function is restored. RATIONALE : Postoperative anastomotic leakage is one of the most devastating and feared complications in colorectal surgery. The risk of postoperative anastomotic leakage varies ...

Phase

A Phase 1 & 2 Study of the Safety, Tolerability and Efficacy of Varlilumab Administered in Combination With Nivolumab in Advanced Refractory Solid Tumors (Head and Neck, Renal and others). Eligible patients will be enrolled and receive varlilumab in combination with nivolumab (Opdivo). All patients enrolled in the study will ...

Phase

This research study is being done to see if radiation can be avoided for a select group of rectal cancer patients who have a good response to 6 treatments with a chemotherapy combination regimen known as FOLFOX. The proposed study does not use new agents or procedures, but rather sequences ...

Phase N/A

Afatinib and Selumetinib in Advanced KRAS Mutant and PIK3CA Wildtype Colorectal Non-small Cell Lung and Pancreatic Cancer

In a pre-clinical study, treatment of KRAS mutant (KRASm) colorectal cancer (CRC) cell lines with an inhibitor of multiple epidermal growth factor receptor (ErBb) kinases in combination with a MEK-inhibitor resulted in synthetic lethality. MEK inhibition alone in these cells resulted in a strong feedback activation of human epidermal growth ...

Phase