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Kidney Cancer Clinical Trials

A listing of Kidney Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (100) clinical trials

Clinical Manifestations and Molecular Bases of Heritable Urologic Malignant Disorders

Background Disorders under investigation are: Autosomal dominant inherited urologic malignant disorders including: von Hippel- Lindau (VHL), hereditary papillary renal cancer (HPRC), Birt Hogg Dube (BHD) and hereditary leiomyomatosis and renal cell acarcinoma (HLRCC) as well as familial renal cancer. Studies have led to the identification and characterization of the VHL, ...

Phase N/A

Genetic Study of Patients With Inherited Urologic Malignancies

OBJECTIVES: - Characterize the natural and clinical histories of patients with inherited urologic malignancies. - Determine the genetic etiology of inherited urologic malignancies in which the gene defect is unknown, using linkage analysis, positional cloning, and evaluation of candidate genes. - Correlate specific mutations and associated protein domains with disease ...

Phase N/A

Collection of Blood Bone Marrow Tumor or Tissue Samples From Patients With Cancer to Study Drug Resistance

Background Ongoing research in the Experimental and Molecular Therapeutics Sections, NCI, requires the availability of blood, serum, tumor, hair follicle and tissue samples from patients with cancer. Resistance is the underlying cause of treatment failure, and may present as acquired or intrinsic drug resistance. Patients with cancer frequently present with ...

Phase N/A

Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease

Background Kidney, prostate, bladder, testis and penile cancer account for 22% of cancers diagnosed in the United States and are responsible for 10% of cancer deaths each year in the U.S. Understanding the genes and gene pathways that cause genitourinary malignancies will provide the foundation for the development of targeted ...

Phase N/A

Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer

Background BHD is a rare, autosomal dominantly inherited disorder which confers susceptibility to develop multifocal, bilateral renal cancer, spontaneous pneumothorax and fibrofolliculomas. BHD is caused by mutations in the BHD gene located on Chromosome17p11.2. Defining the genetic and biochemical pathways leading to renal tumorigenesis in BHD may lead to the ...

Phase N/A

Genetic Study of Patients and Families With Birt-Hogg-Dube Syndrome

OBJECTIVES: - Define the types and characteristics (e.g., patterns of growth) of renal cancer associated with patients and families with Birt Hogg Dube (BHD) syndrome. - Define the risk of renal cancer and lung cysts in patients with BHD syndrome. - Determine the incidence of germline BHD mutations in patients ...

Phase N/A

Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer

Background Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) is a rare autosomal dominantly inherited disorder which confers susceptibility to develop cutaneous and uterine leiomyomas and renal cell carcinoma. HLRCC is caused by mutations in the Krebs cycle enzyme, fumarate hydratase localized on chromosome 1q42.3-q43. Objectives Define the risk of developing ...

Phase N/A

Intraoperative Imagery of Renal Nodules With Folate-fluorescein Conjugate(EC17)

According to the National Cancer Institute, an estimated 64,770 men and women will be diagnosed with kidney cancer in 2012. Of this number, an estimated 13,570 will die of this disease. Surgery remains one of the best options for patients presenting with operable Stage II or III cancers, however the ...

Phase N/A

Metabolic Changes in Patients With Chronic Cardiopulmonary Disease

This study aims to evaluate prevalence of sarcopenia and cachexia in patients with chronic cardiopulmonary disease. The investigators will also investigate metabolic disorders like glucose metabolism, presence of metabolic syndrome, body composition and histological changes in skeletal muscle and body fat. Finally, patients will be followed for clinical endpoints.

Phase N/A

Genetic Susceptibility to Kidney Cancer

This study will further the understanding of the genetic events leading to the development of RCC; explore the genetic basis for genetic instability and how it affects cancer risk; and eventually provide a means of identifying a subgroup of individuals who are most likely to develop RCC. Such individuals may ...

Phase N/A