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Sarcoidosis Clinical Trials

A listing of Sarcoidosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (10) clinical trials

Ambrisentan (Letairis) for Sarcoidosis Associated Pulmonary Hypertension

Primary Endpoint: Change in 6 minute walk distance. Secondary Endpoints: - Safety - Oxygen saturation at rest and with exercise - Hospitalization - Mortality - WHO functional class - Quality of life as measured by - Short-form 36 - Sarcoidosis Health Questionnaire - Dyspnea as measured by - Borg Dyspnea ...

Phase

Role of Genetic Factors in the Development of Lung Disease

This study is designed to evaluate genetic mechanisms of lung disease by surveying polymorphic genes involved in respiratory function and examining gene expression in the lung cells of individuals with pulmonary disease (e.g., alpha 1-antitrypsin deficiency, asthma, chronic obstructive pulmonary disease, cystic fibrosis, sarcoidosis, history of infection, and genetic mutations ...

Phase N/A

Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT

The molecular and pharmacological effects of bardoxolone methyl are broad through its induction of Nrf2 and suppression of NF-κB. Bardoxolone methyl may therefore address multiple facets of the pathophysiology of PH because it suppresses activation of proinflammatory mediators, enhances endothelial NO bioavailability, improves metabolic dysfunction, suppresses vascular proliferation, and prevents ...

Phase

CNS Sarcoidosis and Acthar Gel

Sarcoidosis is a chronic and frequently progressive systemic disease that affects the central nervous system (CNS) in approximately 5% of patients. The hallmark of the disease is the development of chronic inflammation with formation of non-caseating granulomas that can involve the brain parenchyma and meninges and appear as contrast-enhancing mass ...

Phase

Ocular Sarcoidosis Open Label Trial of ACTHAR Gel

The initial treatment of ocular sarcoidosis usually relies on a combination of topical glucocorticoids and oral glucocorticoids, both of which are associated with significant ocular and systemic toxicities. Steroid-sparing therapies are limited by variable and unpredictable efficacy, prolonged time until clinical response, medication intolerance, and difficulties obtaining payor approval. As ...

Phase N/A