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Knee Replacement Clinical Trials

A listing of Knee Replacement medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (42) clinical trials

First-in-human Single Ascending Dose Study of LNA043 in Patients Scheduled for Total Knee Replacement

This study is designed to evaluate the safety and tolerability of ascending single doses of LNA043 given intra-articularly into the human knee joint prior to its removal at total knee replacement surgery. In addition, this will help to establish the presence of LNA043 within the articular cartilage, assess pharmacokinetics and ...

Phase

A Multicenter Study to Evaluate the ConforMIS iTotal (CR) Knee Replacement System Versus Off-the-Shelf Replacement

Subjects will be randomized to one of two study arms in a 1:1 ratio and be implanted with either an iTotal CR or an off-the-shelf cruciate retaining total knee. Sites will perform the off-the-shelf total knees with patient specific instrumentation (PSI) or conventional instrumentation. At those sites that do not ...

Phase

Triathlon Tritanium Cone Augments Outcomes Study

This study is a prospective, open-label, post-market, non-randomized, multi-center clinical evaluation of the Triathlon TS Total Knee System with Triathlon Tritanium Cone Augments for revision total knee arthroplasty (TKA) in a consecutive series of patients who meet the eligibility criteria. The revision rate of the Triathlon Tritanium Cone Augments is ...

Phase N/A

Study of an All Polyethylene Tibial Component

Thirty consecutive TKA patients under the care of two orthopaedic consultants at the Golden Jubilee National Hospital who meet the inclusion/exclusion criteria will be recruited to the study and will be given the all polyethylene tibia. Participants will return for their standard postoperative followup appointments (6 weeks and 1 year ...

Phase N/A

Understanding GMK Sphere Implant Tibiofemoral Kinematics by Means of Dynamic Videofluoroscopy

The objective of this research project is to perform a comparative study on the in vivo kinematics of the GMK Sphere prosthesis in comparison to the conventional GMK PS Fixed Bearing TKA and the GMK UC Fixed Bearing TKA.

Phase N/A

Virtual vs. Traditional Physical Therapy Following Total Knee Replacement

This study will compare the effects on health service use costs of tele-rehabilitation-supported physical therapy versus traditional home and/or clinic-based physical therapy following total knee replacement (TKR) surgery. It will also examine standard post-surgical clinical measures to confirm non-inferiority of outcomes between groups. A total of 300 patients will receive ...

Phase N/A

Study of Local Administration of DepoTXA for Reduced Bleeding in Subjects Undergoing TKA

Approximately 45 subjects (15 per arm) are planned for enrollment. Subjects will be randomized in a 1:1:1 ratio to receive either DepoTXA 800 mg, DepoTXA 1200 mg, or IV TXA (Cyklokapron® 1 gram).

Phase

Non-Interventional Consecutive and Prospective Study of e.Motion PS Pro Prosthesis in the Total Knee Artroplasty

This post-market clinical follow-up study intends to investigate the survival rate at 5 years of the e.motion® PS Pro System.

Phase N/A

VEGA System Study in the Total Knee Arthroplasty

This post-market clinical follow-up study intends to investigate long-term functionality of the VEGA System®. The design of the VEGA System® is meant to provide the patient with more knee mobility compared to their pre-operative state.The endpoint is the revision of at least one of the prosthesis components

Phase N/A

SWORD Phoenix Versus Standard of Care in the Rehabilitation After Total Knee Replacement

The study was designed to evaluate the effectiveness of a novel kinematic biofeedback system - SWORD Phoenix- in the rehabilitation after total knee replacement . SWORD Phoenix allows the patients to perform independent rehabilitation sessions at home, under remote monitoring from the clinical team. The investigators hypothesize that the clinical ...

Phase N/A