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Polycystic Ovarian Syndrome Clinical Trials

A listing of Polycystic Ovarian Syndrome medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (102) clinical trials

Effect of Metformin on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess

This study will test whether metformin administration can ameliorate androgen (male hormone) overproduction in overweight pubertal girls with androgen excess. The investigators hypothesize that improvement in insulin sensitivity by 12 weeks of metformin administration will improve androgen levels after adrenal stimulation testing with adrenocorticotropic hormone (ACTH) or ovarian stimulation testing ...

Phase N/A

The Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS

Groups Experimental treatment: Metformin-GLP-1 Receptor Agonist Therapy. Regular treatment: Metformin-Oral Contraceptive(OC) Therapy. Time Point: Initial treatment; Post-treatment (4w); Post-treatment (8w); Post-treatment (12w); Assess reproductive functions and cardiovascular risk factors.


Post-Prandial Liver Glucose Metabolism in Polycystic Ovarian Syndrome (PCOS) and Understanding Standard of Care Medications

This will be a cross-sectional study with 4 groups of youth. A 6 hour OGTT (Oral Glucose Tolerance Test) with an oral U-C13 glycerol tracer will be paired with NMR isotopomer analysis of serum samples to describe flux through the hepatic pentose phosphate pathway, TCA cycle and DNL pathways in ...

Phase N/A

A Clinical and Biological Research of Combined Chinese and Western Medicine in the Treatment of PCOS

Dingkundan,Diane-35 each ameliorate PCOS, but they do so by different mechanisms. We generally treat PCOS patients without immediate fertility requirement by short-acting contraceptives,Diane-35 is one of the most commonly used drugs. Dingkundan consists of multiple chinese herbs including ginseng,Panax notoginseng,deer antlers,Carthamus tinctorius L.,Radix Paeoniae Alba,prepared Radix Rehmanniae,Angelica etc., which gains ...


L-carnitine and Metformin in Obese PCOS Women.

the trial aims to compare L-carnitine and plus metformin in clomiphene-resistant obese PCOS women with placebo to state the reproductive and metabolic effects in form of pregnancy and insulin resistance parameters and lipid metabolism.


OCP vs Metformin for Improvement in Clinical Symptoms and Metabolic Markers in Indian PCOS Women

Objective: To assess effectiveness of ISD (Insulin sensitizing drugs) Vs OCP (Combined E&P cyproterone acetate) in improving clinical, hormonal and metabolic features of PCOS( polycystic ovary syndrome)women from India. Intervention Randomized to receive Metformin 1500 mg / day OR OCP (EE+CA) Life style advice to women with BMI ( body ...

Phase N/A

Is There Association Between Vitamin D Levels And Insulin Resistance In Polycystic Ovary Syndrome?

Polycystic ovary syndrome (PCOS) is the most common gynecological endocrinopathy among women of reproductive age. The prevalence of PCOS among such women is estimated to be 6.4% to 6.8% worldwide. PCOS is a heterogeneous androgen excess disorder with different degrees of reproductive and metabolic dysfunctions. There are many considerations to ...

Phase N/A

Does Vitamin D Break the Vicious Circle of Polycystic Ovarian Syndrome of Insuline Resistance ?

Research question: In PCOS patients, is there any effect of vitamin D supplementation therapy on plasma concentrations of adipokines (ghrelin, resistin and adiponectin), follistatin and activins? Research hypothesis: There is a significant effect of vitamin D supplementation therapy on plasma concentrations of adipokines (ghrelin, resistin and adiponectin), follistatin and activin.


Hyperandrogenemia and Altered Day-night LH Pulse Patterns

Late pubertal obese girls with hyperandrogenemia have altered day-night patterns of LH secretion when compared to those without hyperandrogenemia. In addition, a previous study revealed that late pubertal adolescents with hyperandrogenemia demonstrate impaired suppression of LH pulse frequency with estradiol and progesterone administration for one week. This study will address ...


Letrozole Versus Laparoscopic Ovarian Drilling in Polycystic Ovary Syndrome

Polycystic ovary syndrome is the major cause of anovulatory infertility. Clomiphene citrate is the most commonly used oral agent for ovulation induction in this group, but there are some drawbacks with the use of it.