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Breast Cancer Clinical Trials

A listing of Breast Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (560) clinical trials

The relatively restricted C4.4a expression pattern provides a target for the selective delivery of a cytotoxic drug to C4.4.a-expressing tumor cells by means of a suitable antibody-drug conjugate. The subject population eligible for the current study will be those subjects with advanced malignancies known to express C4.4a, which are refractory ...


BAY 1217389 is a potent and highly selective inhibitor of monopolar spindle 1 (MPS1) kinase activity. Human MPS1 is a serine threonine kinase, which functions as a core component of the spindle-assembly checkpoint (SAC), a key surveillance mechanism that monitors the attachment of spindle microtubules to the kinetochores of the ...


Docetaxel With or Without a Phytochemical in Treating Patients With Breast Cancer

OBJECTIVES: Primary - To compare the response rate in HER2-negative patients with locally advanced or metastatic breast cancer or locoregional breast cancer recurrence treated with docetaxel and a dietary phytochemical vs docetaxel alone. Secondary - To compare the overall clinical benefit rate (i.e., objective response plus stable disease) in patients ...


Breast-Conserving Surgery Techniques in Treating Women With Breast Cancer

OBJECTIVES: Primary - Evaluate the percentage of histologically healthy margins maintained during resection in women with breast cancer. Secondary - Evaluate local recurrence at 5 years. - Evaluate aesthetic results. - Evaluate quality of life using the QLQC30 and BR23 questionnaires. OUTLINE: This is a multicenter study. Patients undergo oncoplastic ...


Anastrozole or Fulvestrant in Treating Postmenopausal Patients With Breast Cancer

OBJECTIVES: Primary - Evaluate clinical tumor response at 6 months in patients with hormone-sensitive nonmetastatic breast cancer treated with neoadjuvant anastrozole vs fulvestrant. Secondary - Evaluate tumor regression by mammography and ultrasound in these patients. - Evaluate the rate of breast conservation at 6 months of treatment in these patients. ...


Radiation Therapy With or Without Temozolomide in Treating Women With Brain Metastases and Breast Cancer

OBJECTIVES: Primary - Compare the objective response rate at 6 weeks in women with brain metastases secondary to breast cancer treated with radiotherapy with vs without temozolomide. Secondary - Evaluate the tolerability. - Compare the duration of response. - Compare local progression-free survival. - Compare overall survival. OUTLINE: This is ...