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Heart Failure Clinical Trials

A listing of Heart Failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (496) clinical trials

CORolla TAA for Heart Failure With Preserved Ejection Fraction (HFpEF) and Diastolic Dysfunction (DD)

The study objective is to demonstrate safety and feasibility of the CORolla TAA during 12 months of follow up, and to evaluate the performance of the therapy in relieving symptoms and restore diastolic function in patients with heart failure and preserved ejection fraction.

Phase N/A

Increased Adsorption Membranes During Cardiopulmonary Bypass

After informed consent, on those patients randomized to CPB-OXIRIS, PrismafleX eXeed II (Baxter Gambro) with OXIRIS set will be irrigated with saline during preparation and irrigation of CPB circuit. PrismafleX eXeed II (Baxter Gambro) with OXIRIS set will then be connected to CPB circuit. Blood flow between 200-250 ml/min will ...

Phase N/A

Myocardial Perfusion Oxidative Metabolism and Fibrosis in HFpEF

The investigators hypothesize that HFpEF is associated with reductions in myocardial blood flow and energy utilization and increased myocardial fibrosis as compared to age and gender matched hypertensive and healthy controls. The investigators will test their hypotheses by comparing measurements of myocardial blood flow, energy utilization, and fibrosis between three ...


Indacaterol in Heart Failure Patients: Any Role on Lung Fluid Regulation

The purposes of this study are: 1. To confirm safety of Indacaterol in stable Heart Failure. 2. To determine whether beta 2 alveolar receptor stimulation by Indacaterol is able to ameliorate lung diffusion in heart Failure patients treated with beta blockers. 3. To compare the effects of Indacaterol in patients ...


The Clinical Study of the Safety and Efficacy of Istaroxime in Treatment of Acute Decompensated Heart Failure

To Assess the safety, tolerability and efficacy of two different doses of istaroxime (0.5 and 1.0 g/kg/min), a new agent with lusitropic and inotropic activities that improves the cardiac contraction-relaxation cycle. The 2 doses of istaroxime (0.5 and 1.0 g/kg/min) will be infused i. v. for 24 hours in comparison ...


Evaluation of a Multi-professional Breathlessness Service for Patients With Breathlessness Due to Any Advanced Disease

Breathlessness is a common and distressing symptom in patients with advanced diseases like cancer, chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF) or lung fibrosis, which broadly impacts on patients' quality of life and may result in high burden for carers. This single-blinded randomized controlled fast track trial evaluates ...

Phase N/A

Barostim Therapy for Heart Failure

The purpose of this trial is to develop valid scientific evidence for safety and effectiveness of Baroreflex Activation Therapy with the BAROSTIM NEO System in subjects with heart failure, defined as New York Heart Association (NYHA) functional class III and left ventricular ejection fraction (LVEF) 35% despite being treated with ...

Phase N/A

Endovascular NeuromoDulation Treatment fOr Heart Failure Patients (ENDO-HF)

The purpose of the ENDO-HF study is to determine the safety & performance of the Harmony System for the treatment of heart failure


Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection Fraction

To determine whether treatment with sacubitril/valsartan provides a superior effect on aortic characteristic impedance compared to enalapril in patients with heart failure and reduced ejection fraction (left ventricular ejection fraction [LVEF] 40%) after 12 weeks of treatment. The primary endpoint is the change in aortic characteristic impedance (Zc = dP/dQ ...


Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction

The purpose of this study is to evaluate the effect of LCZ696 compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction. Cognitive function will be assessed using a comprehensive battery of tests with an evaluation of longitudinal change of cognitive domains including memory, ...