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Heart Failure Clinical Trials

A listing of Heart Failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (16) clinical trials

Dietary Nitrates for Heart Failure (HF)

For all studies and sub-studies: All Subjects will be consented. B) All Subjects will give permission for the investigators to review their medical records. For the BRJ main study (acute dose BRJ intervention): After consenting to participate, subjects will be instructed to refrain from spitting or the use of an ...

Phase

Ruboxistaurin in New York Heart Failure Classification III-IV Patients

Ruboxistaurin is a drug initially developed for treatment of diabetic peripheral retinopathy. The proposed indication for ruboxistaurin in this study is the treatment of adult patients with New York Heart Failure Association (NYHA) Class III-IV heart failure. Ruboxistaurin is a protein kinase c-alpha (PKC-alpha) inhibitor and thus will produce an ...

Phase

Randomized Clinical Trial of MRI for Optimal CRT Outcomes

At baseline, patients will have CMR, echocardiography, and cardiopulmonary exercise testing. In patients randomized to CMR guidance for the CRT procedure, LV lead placement will be guided by the MRI information related to scar, activation and anatomy. Patients will have follow-up assessments at 6 and 12 months.

Phase

Inorganic NItrate and EXercise Performance in Heart Failure (iNIX-HF): Dose Response

Subjects will be patients with Heart Failure (HF). All subjects will be consented. All subjects will give permission for the investigators to review their medical records. After consenting to participate, subjects will be instructed to refrain from spitting or the use of an antibacterial mouthwash, antacids, proton pump inhibitors, or ...

Phase

Zepatier For Treatment Of Hepatitis C-Negative Patients Who Receive Heart Transplants From Hepatitis C-Positive Donors (HCV)

Open-labelled pilot clinical trial of Zepatier (MK-5172 and MK-8742/Grazoprevir + Elbasvir) in 10 HCV-negative subjects receiving a heart transplant from a HCV-positive donor. Eligible subjects will receive a heart transplant from a deceased-donor with genotype 1 or 4 HCV, and then will receive 12 weeks of Zepatier after heart transplantation ...

Phase

Influence of Catheter-based Renal Denervation in Diseases With Increased Sympathetic Activity

Inclusion Criteria Individual is 18 years of age. Individual agrees to have all procedures performed, and is competent and willing to provide written, informed consent to participate in the registry. Patient scheduled for renal sympathetic denervation using market-released device. Exclusion Criteria In the eyes of the treating physician, the renal ...

Phase

Control of Sinus Node Tachycardia as an Additional Therapy in Patients With Decompensated Heart Failure

Sympathetic hyperactivity and consequent increase in heart rate (HR) are physiological responses to low cardiac output in patients with decompensated heart failure (DHF). However, elevated HR may become inappropriate in these patients, increasing myocardial oxygen demand and decreasing diastolic filling time and might lead to hemodynamic deterioration, ventricular dysfunction (tachycardiomyopathy) ...

Phase

Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy

Phase I-II Clinical Trial-Safety and efficacy of umbilical-cord-derived mesenchymal stem cell (UC-MSC) in patients with chronic heart ischemia cohort and prospective study. Forty patients will be selected and divided into two groups according to patients' willingness to stem cell treatment. The patients who are willing to receive stem cell transplantation ...

Phase

A Study to Investigate the Safety and Efficacy of a Novel Furosemide Regimen

In this pilot study, the treatment in the hospital setting will simulate how the patient would be treated at home in the feasibility study. The results of this pilot will be used to inform the design of the feasibility study. The future feasibility study will test the concept that removing ...

Phase

Effect of Intravenous Ferrous Sucrose on Exercise Capacity in Chronic Heart Failure

Study Phase and Design: Prospective two-centre, randomized, controlled, open-label, observer-blinded, parallel-group study Primary Objective: To evaluate the effect of intravenous (IV) iron supplementation on exercise tolerance, as determined by peak VO2. Secondary Objectives: - To evaluate the effects of IV iron supplementation on exercise duration, left ventricular (LV) structure and ...

Phase