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Heart Failure Clinical Trials

A listing of Heart Failure medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (28) clinical trials

Patients may be entered in the study who are>18 years of age with at least a 30-day history of NYHA Class II to IV HF and and any documented left ventricular ejection fraction within a year prior to screening and signs of volume overload. Patient Inclusion Criteria: History of chronic ...

Phase

This study is designed to assess the efficacy, safety and tolerability of ixmyelocel-T compared to placebo (vehicle control) when administered via transendocardial catheter-based injections to patients with end stage heart failure due to IDCM, who have no reasonable revascularization options (either surgical or percutaneous interventional) likely to provide clinical benefit. ...

Phase

This study is being done to compare the effects of bucindolol hydrochloride (bucindolol) to metoprolol succinate (Toprol-XL) on the recurrence of symptomatic atrial fibrillation/atrial flutter in patients with heart failure who have a specific genotype for the beta-1 adrenergic receptor.

Phase

PHASE 2A, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE-DOSE, 2-PART STUDY TO ASSESS THE SAFETY, TOLERABILITY AND PHARMACOKINETIC RESPONSE AND EXPLORE THE PHARMACODYNAMIC RESPONSE FOLLOWING 4 WEEKS OF ONCE WEEKLY SUBCUTANEOUS INJECTIONS OF PB1046 IN ADULT SUBJECTS WITH STABLE HEART FAILUREWITH REDUCED EJECTION FRACTION (HFREF) (PART 1) AND IN SUBJECTS WITH CARDIAC DYSFUNCTION ...

Phase

Combined CABG and Stem-Cell Transplantation for Heart Failure

The prevalence of symptomatic heart failure in general population is up to 2% and the prevalence increases rapidly with age. Half of the patients with symptomatic heart failure will die within 4 years of diagnosis.The purpose of this study is to examine the effect of bone marrow-derived stem cell transplantation ...

Phase

Congestive Heart Failure Surgical Treatmment With Autologous Stem Cell Therapy

Primary target: determine the safety of introducing CD 34+ autologous progenitor cells (centrally grafted or mobilized in peripheral blood) in the myocardium of ischemic cardiac disease patients. Secondary target: determine clinical effects of grafted cells on remodeling pathology.

Phase

Confirmation Trial of the Acorn CorCap Cardiac Support Device (CSD) at the Same Time as Mitral Valve Repair

The Acorn CorCap Cardiac Support Device (CSD) is a new therapy for the treatment of heart failure that is designed to reduce left ventricular dilation, which is one of the most important pathophysiological mechanisms underlying the clinical syndrome of heart failure. The Acorn CorCap CSD is intended to reduce wall ...

Phase

A Phase IIa Single-blind Placebo-controlled Crossover Multi-center Randomized Study to Assess the Safety Tolerability and Preliminary Efficacy of a Single Intravenous Dose of Ischemia-tolerant Allogeneic Mesenchymal Bone Marrow Cells to Subjects With Heart Failure of Non-ischemic Etiology

The study will enroll 20 subjects and will consist of 2 cohorts. Enrolled subjects will be randomized at 1:1 into an experimental group (n=10) or a placebo group (n=10), respectively. Subjects in the experimental group will receive 1.5 million cells per kg and subjects in the placebo group will receive ...

Phase

The Clinical Study of the Safety and Efficacy of Istaroxime in Treatment of Acute Decompensated Heart Failure

To Assess the safety, tolerability and efficacy of two different doses of istaroxime (0.5 and 1.0 µg/kg/min), a new agent with lusitropic and inotropic activities that improves the cardiac contraction-relaxation cycle. The 2 doses of istaroxime (0.5 and 1.0 µg/kg/min) will be infused i. v. for 24 hours in comparison ...

Phase

Endovascular NeuromoDulation Treatment fOr Heart Failure Patients (ENDO-HF)

The purpose of the ENDO-HF study is to determine the safety & performance of the Harmony System for the treatment of heart failure

Phase