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Brain Cancer Clinical Trials

A listing of Brain Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (533) clinical trials

Assessment of Optune Therapy for Patients With Newly Diagnosed Glioblastoma Using Advanced MRI

Protocol Summary: Optune therapy is a newly approved treatment for patients with glioblastoma. This therapy demonstrated comparable outcomes for patients with recurrent GBM, in comparison to standard therapies, but better quality of life. More recently, in an interim analysis of 315 patients with GBM, adding TTFields to maintenance temozolomide chemotherapy ...


Development and Validation of Advanced MRI Methods for Clinical Applications

The objectives of this study are to (1) Develop and optimize acquisition methods for MRI-based biomarkers that are indicative of brain tumor pathophysiology. These methods include, but are not limited to, DWI, CEST, and Dynamic Susceptibility Contrast (DSC) and Dynamic Contrast Enhanced (DCE) MRI; and (2) Validate DSC-MRI accuracy by ...

Phase N/A

Hippocampal-sparing Whole Brain Radiotherapy for Brain Metastases From Breast Cancer

Based on evidence that radiation-induced damage to the hippocampus plays a considerable role in neurocognitive decline after cranial irradiation, hippocampal-sparing whole brain radiation therapy (HS-WBRT) has been proposed. This study will investigate the neurocognitive function and prognosis between HS-WBRT and conventional WBRT for the treatment of brain metastases from breast ...

Phase N/A

Spectral Analysis Probe to Identify Glioblastoma Cells

This is a pilot study to investigate if the Chaos Wand Spectral Diagnosis Probe can be used to identify Glioblastoma (GBM) cancer cells in patients undergoing standard surgical resection. Eligible patients who have consented to the use of the Chaos Wand will be scheduled for surgery as standard cancer care ...

Phase N/A

CEST- Glucose Enhanced MRI for Metastatic Brain Tumours

Purpose: To quantitatively compare glucose-enhanced MRI with the current standard GBCA enhanced MRI in participants with metastatic brain tumours prior to receiving radiotherapy from British Columbia Cancer Agency at Vancouver Cancer Centre. Hypotheses: 1) Glucose enhanced MRI will highlight malignant metastatic brain tumours with comparable contrast to noise compared to ...


Astrocytoma / Desmoplastic Gamliogliomes (DIA / DIG) - Study of the French Cohort of the Last 20 Years : Clinical Anatomopathological Molecular and Radiological Charactersics

Astrocytomas / infantile desmoplastic gangliogliomas (DIA / DIG) are rare brain tumors usually affecting infants. They represent about 0.5% of all pediatric brain tumors. DIA / DIG occurs mainly in the first 2 years of life, with a sex ratio M / F of 1.7 to 1. From a histological ...

Phase N/A

Personalized Cellular Vaccine for Recurrent Glioblastoma (PERCELLVAC2)

This is an open label, single-arm, single-institution, Phase I/II study designed to investigate the safety and efficacy of personalized cellular vaccines for patients with recurrent glioblastoma (GBM). Recurrent GBM patients will undergo tumor resection. The tumors will be analyzed for the expression of a panel of glioma-associated antigens and immune-related ...


Trial of Hypofractionated Radiation Therapy for Glioblastoma

Hypofractionated radiation therapy (RT) in the treatment of patients with glioblastoma, 18 - 70 years of age with good performance status (ECOG 0 - 2), will be well tolerated and yield survival non-inferior to conventional fractioned RT, allowing significant abbreviation of the length of the radiation course required for these ...


Surgery for Recurrent Glioblastoma

Background Glioblastoma is a malignant, locally invasive brain tumor whose prognosis remains grim despite various intense treatment modalities. In the past, radical surgery was met with skepticism due to the aggressive infiltrative character of the tumor. However, an increasing number of retrospective studies over the last decade suggest a survival ...


Ferumoxytol MRI in Assessing Response to Pembrolizumab in Patients With Brain Tumors From Melanoma and Glioblastoma

PRIMARY OBJECTIVES: I. Determine the sensitivity and specificity of relative cerebral blood volume (rCBV) measured by steady state MRI with ferumoxytol in identifying true versus (vs) pseudoprogression in melanoma patients with brain metastases that receive pembrolizumab with standard of care stereotactic radiosurgery. (Arm 1) II. Determine the sensitivity and specificity ...