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Brain Cancer Clinical Trials

A listing of Brain Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (51) clinical trials

A clinical trial sponsored by Massachusetts General Hospital for a research study of Ipilimumab, Nivolumab

This research study is a Phase II clinical trial. Researchers hope to study the effects of the combination of Nivolumab and Ipilimumab. Many cancers use specific pathways (such as PD-1/PD-L1 and CTLA-4) to evade the body's immune system. Nivolumab and ipilimumab work by blocking the PD-1/PD-L1 and CTLA-4 pathways and ...


A clinical trial sponsored by AbbVie for a research study of Temozolomide, ABT-414, Lomustine

The pediatric sub-study is an uncontrolled, open-label, single-arm global study. This sub-study is to evaluate the safety, tolerability, and pharmacokinetics of ABT-414 in a pediatric population less than 18 years of age as well as to assess the effect of ABT-414 on tumor response per Response Assessment in Neuro-Oncology (RANO) ...


A clinical trial to evaluate treatments for patients with Malignant neoplasm of brain

Consenting subjects who have met inclusion and exclusion criteria will be enrolled to receive either fluorescein+ALA or fluorescein alone. HGG patients will be randomized on a 2 to 1 basis to receive either both fluorescein and ALA or fluorescein alone, and LGG patients will be randomized on a 1 to ...


A Phase 2 clinical study for patients with Gliomatosis cerebri, Neoplasm by Histologic Type, Glioma, Malignant neoplasm of brain, nervous system disorder, Neuroectodermal Tumor, gliosarcoma, Glioblastoma Multiforme, Neoplasms, Nerve Tissue

In the initial phase of the study, up to 12 evaluable subjects will be enrolled in 3 dose cohorts to determine the best dose of DNX-2401, as follows: Cohort 1: Single dose DNX-2401 (5e8 vp) delivered intratumorally by cannula, followed by intravenous pembrolizumab every 3 weeks (Q3W) Cohort 2: Single ...


A clinical trial to evaluate treatments for patients with Brain Metastases From Non-small Cell Lung Cancer (NSCLC)

PAST PRE-CLINICAL AND CLINICAL EXPERIENCE: The effect of the electric fields (TTFields, TTF) has demonstrated significant activity in in vitro and in vivo NSCLC pre-clinical models both as a single modality treatment and in combination with chemotherapies. TTFields have also shown to inhibit metastatic spread of malignant melanoma in in ...


A clinical trial seeking patients for a research study for the treatment of Craniopharyngioma, Cushing's Syndrome, Pituitary Adenoma, Atresia, Endocrine disorder, CONGENITAL ANOMALY NOS

There are a variety of tumors affecting the pituitary gland; The gene(s) involved in the pathogenesis of these tumors are largely not known; their possible association with other developmental defects or inheritance pattern(s) has not been investigated. The present study serves as a (i) screening/training, and, (ii) a research protocol. ...

Phase N/A

A clinical research study for the treatment of Hereditary Neoplastic Syndrome, Tuberous Sclerosis

Patients with tuberous sclerosis develop benign cutaneous tumors that are typically multiple in number and location. These tumors include facial angiofibromas, forehead plaques, shagreen patches, periungual fibromas, and gingival fibromas. The tumors are permanent, slow growing, and often disfiguring. The purpose of this study is to elucidate the molecular basis ...

Phase N/A

Patients are needed to participate in a clinical research study to evaluate Malignant neoplasm of brain

Background Children with brain tumors are generally followed for response or progression by imaging studies, such as CT or MRI. While these imaging studies help delineate the anatomical location and extent of a tumor within the CNS, they give no information regarding the biologic or metabolic activity of the lesion. ...

Phase N/A

A clinical trial sponsored by National Cancer Institute (NCI) for a research study for the treatment of Optic Nerve Glioma, von Recklinghausen's Disease, Plexiform Neurofibroma, Nerve Sheath Tumors, neurofibroma

BACKGROUND Neurofibromatosis Type 1 (NF1) is an autosomal dominant, progressive genetic disorder characterized by diverse clinical manifestations. Patients with NF1 have an increased risk of developing tumors of the central and peripheral nervous system including plexiform neurofibromas (PN), dermal neurofibromas, optic pathway tumors, brain tumors, malignant peripheral nerve sheath tumors ...

Phase N/A

Patients are needed to participate in a clinical research study evaluating Carboplatin, Vincristine, Bevacizumab, Irinotecan, Mebendazole, Temozolomide for the treatment of Diffuse Intrinsic Pontine Glioma, Pleomorphic Xanthoastrocytoma, Astrocytoma, Optic Nerve Glioma, gliosarcoma, Glioblastoma Multiforme, Brainstem Glioma, Low Grade Glioma, Pilomyxoid Astrocytoma, DIPG

This is a phase I/II study of mebendazole in combination with standard of care agents for pediatric patients with gliomas. Patients with low-grade gliomas will receive a regimen of mebendazole in combination with vincristine, carboplatin, and temozolomide. Patients with high-grade gliomas and diffuse intrinsic pontine gliomas will receive a regimen ...