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Brain Cancer Clinical Trials

A listing of Brain Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (49) clinical trials

To demonstrate the antitumor activity of Antineoplaston A10 and AS2-1 in the treatment of children with primary malignant brain tumors by determining the proportion of patients who experience an objective tumor response. To evaluate the adverse effects and tolerance of Antineoplaston A10 and AS2-1 in these patients. Inclusion Criteria Patients ...

Phase

Stereotactic Radiosurgery to the Resection Cavity Following Surgical Removal of Brain Metastasis

Study Purpose Treatment strategies for recurrent brain metastasis Limited clinical data support interventions for recurrent BM such as WBRT, re-operation or SRS, depending on previous treatments (6, 45, 48). Two retrospective analyses looked at a total of 130 non-small cell lung cancer (NSCLC) patients with recurrent BM after resection (6, ...

Phase

Vaccine Therapy and GM-CSF in Treating Patients With CNS Lymphoma

OBJECTIVES: Primary - To determine the proportion of patients with CNS lymphoma who develop anti-idiotype (Id) and anti-keyhole limpet hemocyanin (KLH) humoral immune responses in the serum and/or CSF following patient-specific immunotherapy comprising recombinant tumor-derived immunoglobulin Id-KLH conjugate vaccine and sargramostim (GM-CSF). - To assess the safety and tolerability of ...

Phase

External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases

OBJECTIVES: - Compare the efficacy, in terms of time to treatment failure at CNS level and 4-months treatment failure rate, in patients with brain metastases treated with external-beam radiotherapy in combination with indinavir sulfate and ritonavir versus external-beam radiotherapy alone. - Prospectively investigate the efficacy of a potentially antiangiogenic agent, ...

Phase

Ferumoxytol- and Gadolinium-Labeled MRI in Measuring Tumors Before or After Treatment in Patients With Primary or Metastatic Brain Tumors

PRIMARY OBJECTIVES: I. To compare quantitative blood brain barrier permeability measurements (derived transfer coefficient [Ktrans]) of a standard gadolinium (Gd) MRI contrast agent at 3T and 7T using dynamic contrast enhancement (DCE) MRI. II. To compare dynamic susceptibility contrast (DSC) based perfusion measures at 3T and 7T. SECONDARY OBJECTIVES: I. ...

Phase

High Risk Primitive Neuroectodermal (PNET) Brain Tumors in Childhood

The purpose of this study is to evaluate the efficacy of the combination of surgery, conventional chemotherapy, sequential high-dose chemotherapy with peripheral blood stem cell transplantation and reduced dose radiation therapy in high-risk PNET brain tumors.

Phase

Study of Vinorelbine and Cyclofosfamide Among Patients With Refractory Tumours or in Relapse

This is a phase II study to determine the antitumor activity of Vinorelbine and Cyclofosfamide association among patients with refractory tumours or in relapse with rhabdomyosarcomas and other soft tissue tumours, Ewing tumours, osteosarcomas, neuroblastomas or medulloblastomas.

Phase

Chemotherapy and HAART to Treat AIDS-related Primary Brain Lymphoma

Background: AIDS-related primary central nervous system lymphoma (AR-PCNSL) is an Epstein-Barr virus (EBV)-driven lymphoproliferative process that typically results in death within a few months. Essentially all of the cases are immunoblastic CD20+ tumors, and occur once the CD4+ cells have fallen to below 50 cells/mm3 . Highly active antiretroviral therapy ...

Phase

Secured Access to Pembrolizumab for Adult Patients With Selected Rare Cancer Types

The study plans to enrol up to 300 patients in total with between 20 and 50 patients assigned to each cohort according to indication, as follows: - Cohort 1: Rare sarcoma - Cohort 2: Rare ovarian cancer - Cohort 3: Primary central nervous system lymphomas - Cohort 4: Rare thyroid ...

Phase