Home » Clinical Trials »  Search Clinical Trials

Therapeutic Areas:  |  Dermatology

Search Medical Condition
Please enter condition
Please choose location from dropdown
Clear Trial Filters

Ichthyosis Clinical Trials

A listing of Ichthyosis medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (18) clinical trials

Are you Living with Sjögren’s Syndrome? Sjögren’s syndrome is a condition that causes the body's immune system to attack its own healthy cells. This can result in painfully dry eyes and mouth, swollen joints and skin rashes. It can also affect organs like the kidneys, liver, or lungs.  Sjögren’s syndrome ...

Phase N/A

Ophthalmological Abnormalities in Hereditary Ichthyosis (ICHTYO-KERATO)

Background: Hereditary ichthyosis are rare genetic diseases characterized by an abnormal epithelial keratinization due to mutations in gene involved in skin barrier. Patients present with scales on the whole body. Recent classification basically distinguishes syndromic from non-syndromic forms. Ichthyoses are severe diseases with significant impact on quality of life, due ...

Phase N/A

Defining the Skin and Blood Biomarkers of Ichthyosis

Objectives To define a panel of skin and blood biomarkers associated with disease activity and pruritus in Netherton syndrome, lamellar ichthyosis, and other ichthyosis subtypes. To determine if blood samples can serve as surrogates for skin immune activation and will correlate with disease severity. To determine FLG, SPINK5, TGM1, or ...

Phase N/A

Fecal Bile Acids Fecal Short Chain Fatty Acids and the Intestinal Microbioita in Patients With IBS and Control Volunteers

There is emerging evidence that alterations in bile acids and SCFA associated with IBS could be associated with changes in the gut microbiota. In addition to modulating levels of intraluminal organic acids, it has been hypothesized that gut microbiota may alter local immune responses, modulate visceral pain responses, and impair ...

Phase N/A

The Efficacy and Safety of Secukinumab in Patients With Ichthyoses

The ichthyoses are a group of lifelong genetic disorders which share characteristics of generalized skin thickening, scaling and underlying cutaneous inflammation. The vast majority are orphan disorders and are associated with extremely poor quality of life related to social ostracism from altered appearance, associated itchiness and discomfort, and functional limitations ...

Phase

Gene Therapy for Netherton Syndrome

Netherton Syndrome is a serious skin disorder caused by damage in a gene called SPINK5. This gene controls the formation of a protein called LEKTI, which important for skin barrier function. LEKTI inhibits certain enzymes (serine proteinases) in the outermost layer of the skin (epidermis). The function of the serine ...

Phase

Integrative Approaches to Managing Irritable Bowel Syndrome (IBS)

This project will test the effectiveness of an integrative medicine approach in treating irritable bowel syndrome (IBS). Over the course of 18 months, we will recruit 85 participants with IBS in New York City. These participants will be randomized to either a 4-week group-oriented treatment intervention incorporating a low FODMAP ...

Phase N/A

Visceral Sensitivity in IBD (Irritable Bowel Disease) and IBS (Irritable Bowel Syndrome)

Methods Sample collection in healthy subjects, IBD and IBS patients: biopsy of rectum and colon descendens blood sample collection collection of sample of nasal mucosa feces collection questionnaires rectal barostat sensitivity measurement transit measurement of colon MR scan of brain

Phase N/A

Confocal Laser Endomicroscopy in IBS Patients

This study will assess dynamic effects of two major antigens on the duodenal mucosa by confocal laser endomicroscopy (CLE). Patients will be blinded to the antigens used (wheat, yeast). Following CLE it is planned to have a cross over exclusion diet with/without the antigens including a washout phase. Furthermore, patients ...

Phase N/A

Measuring Nerve Activity in Small Human Intestinal Biopsies in IBS (Irritable Bowel Syndrome)

Rectal biopsies from IBS patients or healthy subjects will be taken. Biopsies will be used for: the isolation of submucosal plexus to perform: 1.1 live nerve recordings and Calcium imaging; 1.2 immunohistochemistry; 1.3 mRNA (Messenger ribonucleic acids) isolation and real time PCR (Polymerase chain reaction); culturing biopsies On the basis ...

Phase N/A