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Fever Clinical Trials

A listing of Fever medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (297) clinical trials

SJ733 Induced Blood Stage Malaria Challenge Study

Each participant in the cohort will be inoculated on Day 0 with ~2,800 viable Plasmodium falciparum-infected human erythrocytes (BSPC) administered intravenously. On an outpatient basis, participants will be monitored daily via phone call and then will attend the clinic daily (AM) from day 4 (until PCR positive for presence of ...

Phase

Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock Trial. VIPER-Sepsis (EudraCT no. 2016-000707-81)

Recently a great interest in the role of the endothelium in the pathophysiology of sepsis has been introduced. The endothelium is coated by a "thick" endothelial glycocalyx protecting it from becoming activated and prevents capillary leakage. The glycocalyx binds approximately 1-1.5 litres of the plasma portion of the circulating blood ...

Phase

A FIH Study to Investigate the Safety Tolerability and PK of P218

The study is divided into two parts: Part A This is a double-blind randomised, placebo-controlled, parallel group, ascending dose study and will comprise up to eight fasted cohorts (8 volunteers in each) that will receive a single ascending dose (SAD) of P218 to assess its safety, tolerability and pharmacokinetic profile. ...

Phase

Cost-effectiveness Evaluation of Vector Control Strategies in Mozambique

Mopeia is a district in the Zambezia Province. Mopeia borders the district of Morrumbala to the North, the district of Chinde and the province of Sofala to the South, the districts of Nicoadala and Inhassunge in the East and the Provinces of Sofala and Tete in the West. It has ...

Phase N/A

Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics

The purpose of this protocol is to study the genetics and pathophysiology of familial Mediterranean fever (FMF) and other related diseases. FMF is a recessively inherited condition characterized by episodes of fever and serositis or synovitis; some patients also develop systemic amyloidosis. Our laboratory has identified the FMF gene and ...

Phase N/A

Natural History of Anthrax: a Study of Primary Infected Recovered and Exposed Individuals (SPoRE); and Evaluation of AVA-Vaccinated Recipients

The intentional use of Bacillus anthracis in 2001 as a bioterrorism weapon with fatal consequences renewed interest in past epidemiologic and animal research about pathogenesis and posed new dilemmas about diagnosis and treatment. Cases in the October 2001 US outbreak were theoretically exposed via one dispersal method: aerosolization of Ames ...

Phase N/A

Impact of CVVHD With Increased Adsorption Membranes in Septic Acute Kidney Injury

Investigators will warrant a correct protocol application. Study data will be reviewed by an external monitoring committee from the clinical assay research central unit (UCICEC - IDIBELL). Monitors will contrast registered data from the collection data form (CDF) with data from patients medical record. All patients medical records will be ...

Phase N/A

Immunity Period After One Dose of Yellow Fever Vaccine in Adults and Children (Paraiba Study)

This is a Phase IV study cohort, uncontrolled, composed of two segments: children and healthy adults. It will be included 2756 children and 2005 adults, evaluated initially in six different times (before vaccination, 30-45 days, 1 year, 4 years, 7 years and 10 years after vaccination). The Paraiba state was ...

Phase

Cisplatin Metronomic Low-Dose Interferon Alfa Gemcitabine and Fever-Range Whole-Body Hyperthermia in Treating Patients With Inoperable or Metastatic Pancreatic Cancer

OBJECTIVES: Primary - Determine tumor response in patients with inoperable or metastatic pancreatic cancer treated with cisplatin, metronomic low-dose interferon alfa, gemcitabine, and fever-range whole-body hyperthermia. - Determine the toxicity of this regimen in these patients. - Determine the survival of patients treated with this regimen. - Determine changes in ...

Phase

Levosimendan Versus Dobutamine in Shock Patients

The purpose of the study is to compare the efficacy of levosimendan with that of dobutamine in patients with unstable hemodynamics (shock).

Phase