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Fever Clinical Trials

A listing of Fever medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (30) clinical trials

PfSPZ Vaccine: Dose Optimization With Heterologous Challenge in Healthy Malaria-Na ve Adults

The study will be conducted as a collaborative effort between the NMRC, UMB CVD, WRAIR and Sanaria, Inc. The study screening, immunizations and follow-ups for Groups 1 & 2 will take place at the UMB CVD. The study screening, immunizations and follow-ups for Groups 3 & 4 will take place ...


Safety Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold Sores

The primary endpoint of this study are: - "Time to healing" - Clinician-assessed duration in days of herpes labialis episode. - Patient-assessed duration and intensity of pain by Visual Analog Scale (VAS). - Safety and tolerability following five consecutive treatment days with five times daily topical administration. The secondary endpoints ...


Esmolol Effects on Heart and Inflammation in Septic Shock

Beta adrenergic system, over-activated in septic shock patients, is a key modulator of the inflammatory response. Experimental works demonstrated that Esmolol, an highly selective beta-1 blocker, reduces heart rate and regulates the inflammatory response. A recent mono centric, double blind, randomized clinical work in septic shock patients has shown that ...


Pilot Phase II Study: Hemodynamic Tolerance and Anti-inflammatory Effects of Esmolol During the Treatment of Septic Shock

During septic shock, the consequences of treatment by a 1-blocker on inflammation and cardiovascular variability are unknown. The use of esmolol should have positive effects on inflammation and hemodynamic tolerance. These effects are probably dose-dependent. The study will enroll adult patients hospitalized in ICU, for severe septic shock requiring treatment ...


Clinical Trial of the BioMed rTSST 1 Variant Vaccine in Healthy Adults

The BioMed rTSST-1 Variant Vaccine has been developed by Biomedizinische ForschungsgmbH as one component of a polyvalent staphylococcal vaccine for the prevention of toxic shock and hyperimmunization of donors for the production of TSST-1 immunoglobulin. This is a prospective, randomized, parallel control, phase 2 study of extended safety, local tolerance, ...


Cisplatin Metronomic Low-Dose Interferon Alfa Gemcitabine and Fever-Range Whole-Body Hyperthermia in Treating Patients With Inoperable or Metastatic Pancreatic Cancer

OBJECTIVES: Primary - Determine tumor response in patients with inoperable or metastatic pancreatic cancer treated with cisplatin, metronomic low-dose interferon alfa, gemcitabine, and fever-range whole-body hyperthermia. - Determine the toxicity of this regimen in these patients. - Determine the survival of patients treated with this regimen. - Determine changes in ...


The Efficacy and Safety of ITF2357 in AIS

Rationale: Autoinflammatory syndromes (AIS) are a group of disorders characterized by recurrent episodes of inflammation. This occurs in the absence of autoantibodies and antigen specific T cells. To date 6 genetically distinct hereditary autoinflammatory syndromes are known and more recently other sporadic syndromes, such as the Schnitzler’s syndrome (urticaria, periodic ...


Orthostatic Hypotension in Children With Acute Febrile Illness

Orthosatic hypotension describes a condition in which the autonomic nervous system fails to maintain a stable blood pressure in the face of postural change. Children presenting to the pediatric ED with fever often describe symptom like syncope, lightheadedness, dizziness, pallor, fatigue and weakness. These symptom may result from orthostatism related ...


Angiotensin in Septic Kidney Injury Trial

Sepsis is the most common cause of ARF in the ICU. In last 50 years there have been no significant advances in our understanding of the pathogenesis, prevention or treatment of septic ARF, except for the use of renal replacement therapy (RRT) once it is established. It has been assumed ...


Immunogenicity Efficacy and Safety Study of an MSP3-LSP (Long Synthetic Peptide) Malaria Vaccine

This will be a double blind, randomized, placebo-controlled phase IIb study to evaluate the immunogenicity, efficacy and safety of Plasmodium falciparum vaccine candidate, Merozoite Surface Protein-3 Long synthetic peptide (MSP3) adjuvanted in aluminium hydroxide versus Verorab control in healthy children aged 12-48 months in Mali A phase Ib trial is ...