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Achalasia Clinical Trials

A listing of Achalasia medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (32) clinical trials

Genetic Mosaicism in Hirschsprung's Disease

Hirschsprung's disease is a complex genetic disorder. The etiology of this disease is not completely understood. It is characterized by the absence of ganglia (nerve cells) in de distal colon. This impairs bowel relaxation which can lead to bowel disfunction, toxic megacolon, ileus and enterocolitis. So far, several genes have ...

Phase N/A

Minimally Invasive Surgery of the Gastro-esophageal Junction

This study will assess short and long term outcomes of individuals undergoing minimally invasive surgery of the gastro-esophageal junction (MISGEJ). Patients will respond to questionnaires on an annual basis evaluating quality of life and functionality following MISGEJ. Hospital charts will also be reviewed on an annual basis to assess patient ...

Phase N/A

POEM- Peroral Endoscopic Myotomy for Esophageal Motility Disorders

POEM has recently described as an alternative treatment for achalasia in humans. In this procedure the esophageal sphincter is incised through a submucosal tunnel in the esophagus. In this study we aim to perform POEM on achalasia patients.

Phase N/A

Outcome of Symptoms in Patients Undergoing a Heller Myotomy

Patients will answer questionnaires before and after surgery to evaluate their symptoms of achalasia and will also have their charts reviewed for relevant medical information.

Phase N/A

Anterior Orientation vs Posterior Orientation in Per Oral Endoscopic Myotomy POEM for the Treatment of Achalasia

Achalasia is one of the most studied esophageal motility disorders. The etiology of Achalasia is autoimmune, neurodegenerative, or viral immune. Achalasia is a consequence of the degeneration of ganglion cells in the myenteric plexus of the esophageal body and the lower esophageal sphincter (LES). The end result of the inflammatory ...

Phase N/A

Per-Oral Endoscopic Myotomy

This is a prospective chart review/data collection study of the per oral endoscopic myotomy (POEM) procedure, that will include questionnaires administered throughout the study. Subjects enrolled will be those intending to have a POEM procedure. Data will be collected and reviewed through 12 months post-op.


Peroral Endoscopic Myotomy (POEM) for the Treatment of Achalasia

Information about the subject's medical history, leading up to the need for an Achalasia treatment, the procedure itself and how the subject does after the procedure, including after the subject gets home, will be collected. This will be done by gathering relevant information from the subject's medical chart and/or by ...

Phase N/A

Endoscopic Myotomy of the Lower Esophageal Sphincter for Achalasia

By the endoscopic creation of an esophageal submucosal tunnel the inner circular muscle layer can be easily visualized. In contrast to conventional Heller myotomy, the dissection of only the inner circular esophageal muscle layer leaves the outer longitudinal muscle layer intact. Thereby, post-interventional reflux disease should be avoided.

Phase N/A

Achalasia and Dysplasia

Patient with achalasia have a 10-50 fold increased risk to develop esophageal squamous cell carcinoma (ESCC). Early diagnosis of ESCC is essential, and detection of an earlier dysplastic stage is preferred. Endoscopic detection is however difficult and often delayed. Chromoendoscopy with Lugol dye increases detection rates dysplasia and ESCC to ...

Phase N/A

POEM for Spastic Esophageal Disorders

Standard surgical care for spastic esophageal disorders such as achalasia includes a procedure called Heller myotomy. The treatment in our study, called endoscopic myotomy (also known as peroral endoscopic myotomy - POEM) is different from standard surgery (Heller myotomy) because it is less invasive, is less likely to cause reflux, ...

Phase N/A