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Thymomas Clinical Trials

A listing of Thymomas medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (15) clinical trials

MK-3475 in Patients With Thymic Carcinoma

This is a phase II study of MK-3475 in thymic carcinoma patients after at least one prior chemotherapy regimen. Exploratory studies will be performed on archival tumor material (PDL-1 expression, next-generation sequencing) and fresh biopsies (culturing, next-generation sequencing). Simon's two-stage optimal design is used. The null hypothesis that the true ...


A Study of BKM120 (Buparlisib) in Relapsed or Refractory Thymomas

Thymic tumors are rare tumors, but represent the most common tumors of the anterior mediastinum. Thymoma has an indolent course in advanced disease and has the propensity to spread to the pleura. In first line therapy, combination chemotherapy produces responses in approximately 80% of patients. A number of single agents ...


Study of Patients With Non-Small Cell Lung Cancer Esophageal Cancer Malignant Pleural Mesothelioma Mediastinal or Chest Wall Neoplasms or Lung Metastases From Cancers of Non-Thoracic Origin

OBJECTIVES: - Evaluate patients referred to the Thoracic Oncology Section of the Surgery Branch, NCI in order to identify patients who are suitable candidates for clinical research protocols. - Obtain biopsies during staging studies of tumor and adjacent normal tissues as well as serum and urine samples from patients with ...

Phase N/A

Postoperative Conformal Radiotherapy for Stage II-III B Type Thymoma

The role of postoperative radiotherapy in thymoma is controversial. Some retrospective studies were for the radiotherapy, but others were against. However, more inherent biases existed in these trials. Resection, Masaoka stage and pathology were widely accepted as the prognostic factors for thymoma. Furthermore, the frequency of local failure after radical ...


Study of Chemoradiotherapy for Inoperable Locally Advanced (Stage / a) Thymoma or Thymic Carcinoma

Complete resection is difficult to achieve without damaging the main organs in some locally advanced thymoma or thymic carcinoma. The previous trials have showed that radiotherapy was significantly associated with prolonged OS and chemotherapy is playing an increasing role in treatment of patients with advanced thymoma or thymic carcinoma. However, ...


Confocal Laser Endomicroscopy in Pleural Malignancies

Novel optical imaging techniques such as confocal laser endomicroscopy (CLE) have emerged in recent years as techniques that actually enable in vivo real-time microscopic analysis of malignancies of the GI-tract and lung cancer. Through recent advances the probe became small enough to fit through a biopsy needle and can be ...

Phase N/A

Feasibility Trial of Pembrolizumab in Unresectable Thymoma and Thymic Carcinoma

Study Groups: If you are found to be eligible to take part in this study, you will be assigned to a study group based on when you join this study. Up to 6 participants will be enrolled in Part 1 of the study, and up to 24 participants will be ...


Molecular Profiling and Targeted Therapy for Advanced Non-Small Cell Lung Cancer Small Cell Lung Cancer and Thymic Malignancies

BACKGROUND A better understanding of the genetic make-up of the individual tumor may offer potentially improved therapies. This approach may also give rapid access to response data in patients with sometimes rare genetic abnormalities. In addition, it will allow us to test targeted therapies in a select population of patients ...


Adjuvant Radiotherapy for Stage II/III Thymoma After Complete Resection

It is confirmed by many studies that patients of thymoma with complete resection have better prognosis than those with either incomplete resection or without surgery. However,whether patients with stage II or III thymoma could benefit from adjuvant radiotherapy after complete resection remains controversial. The purpose of this study is to ...

Phase N/A

Adjuvant Treatment for Incomplete Resection Thymoma or Thymic Carcinoma

The previous trials have showed that radiotherapy was significantly associated with prolonged OS and chemotherapy is playing an increasing role in treatment of patients with thymoma or thymic carcinoma.However,whether patients with thymoma or thymic carcinoma could benefit from adjuvant radiochemotherapy after incomplete resection remains controversial. The purpose of this study ...