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Atrial Fibrillation Clinical Trials

A listing of Atrial Fibrillation medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (460) clinical trials

STOP AF First: Cryoballoon Catheter Ablation in an Antiarrhythmic Drug Naive Paroxysmal Atrial Fibrillation

Subjects with paroxysmal atrial fibrillation with no history of treatment with anti-arrhythmic drugs are randomized 1:1 to either an anti-arrhythmic drug or pulmonary vein isolation using the cryoballon catheter.

Phase N/A

A Study to Quantify Use of Anticoagulation to Improve Management of Atrial Fibrillation

The purpose of this study is to evaluate the impact of a hospital quality improvement (QI) program on the use of guideline-recommended oral anticoagulants (OAC) in hospitalized patients with atrial fibrillation (AF) at risk for ischemic stroke. Specifically, the study will determine whether the intervention, compared to Usual Care, will ...

Phase N/A

Pulmonary Vein Isolation in Athletes

Endurance athletes with paroxysmal or persistent atrial fibrillation undergoing primary pulmonary vein isolation will be prospectively enrolled prior to PVI. Patients will undergo metabolic exercise stress testing as well as resting CMR 1-4 weeks prior to PVI. Metabolic stress testing and CMR will be repeated at 6 month follow-up. Quality ...

Phase N/A

ECGi Ibutilide: Effect of Ibutilide on AF Source Location and Organization

This prospective, multicenter observational study will examine the ability of ECGi mapping to Effect of Ibutilide on the number and size of the driver domains Effect of ablation of Ibutilide-organized driver domains Effect of PV isolation on driver domains The researchers hypothesize that this approach will lead to successful arrhythmia ...

Phase N/A

Optimal Delay Time to Initiate Anticoagulation After Ischemic Stroke in Atrial Fibrillation

Long-term oral anticoagulation is standard for secondary stroke prevention in patients with atrial fibrillation (AFib). However, there is limited data and no consensus on the timing of when to initiate anticoagulation therapy, and concern that starting too soon risks symptomatic hemorrhagic transformation. These data are derived almost exclusively from heparins ...


Arrhythmias in Post-Myocardial Infarction Patients

Patients with acute myocardial infarction have exceptionally high mortality rates exceeding 10% during the first year post-MI. The incidence of sudden cardiac death after acute myocardial infarction is the same with ST-elevation and non-ST elevation myocardial infarction. The risk of disabling stroke and sudden cardiac death is high especially during ...

Phase N/A

Ibutilide Administration During Pulmonary Vein Ablation

To test the hypothesis that localized functional reentry maintains Afib in humans, ibutilide will be administered intravenously in patients undergoing an Afib ablation. The hypothesis of this study is that ibutilide will decrease the high frequency signals observed in Afib suggesting the presence of micro reentrant circuits as the basic ...

Phase N/A

Pulmonary Vein (PV) -Isolation: Arrhythmogenic Vein(s) Versus All Veins

BACKGROUND Atrial fibrillation ablation procedures typically involve isolation of all pulmonary veins (PVs), yet the need for such an extensive ablation strategy in all patients is unclear. OBJECTIVE: We conduct a randomized study comparing the safety and effectiveness of two interventional ablation techniques for treatment of paroxysmal atrial fibrillation: the ...


Irbesartan and Adhesion Molecules in AF

Primary Objective: The aim of the study is to assess that blocking the angiotensin II type 1 receptor reduces systemic levels of oxidative stress markers and adhesion molecules by more than 25% compared to placebo in patients with persistent/permanent atrial fibrillation. Primary Target Parameter: The primary target parameter is defined ...


The Effect of Losartan on Atrial Fibrillation (AF) Burden and Pacemaker Dependence in Patients With Sick Sinus Syndrome

Sick sinus syndrome is a common indication for permanent cardiac pacing in the community. It results from disordered impulse generation within the sinus node or impaired conduction of the impulse to the surrounding atrial tissue, thus leading to the clinical manifestation of bradycardia. In patients with SSS, AF frequently develops ...

Phase N/A