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Addictions Clinical Trials

A listing of Addictions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (288) clinical trials

A Brain Imaging Study Into Nicotine Induced Dopamine Release in Cigarette Smokers.

Dopamine plays a critical role in nicotine(and other) addiction and this drug is known to release DA in brain areas mediating reward and motivational processes. Although imaging studies show that release of DA follows smoking, little is known regarding how common some genetic polymorphisms proposed to play a role in ...

Phase N/A

Substance Abuse Pre-Treatment Screening Study

Approximately 1500 candidates per year will respond to advertisements and will complete preliminary telephone screening without identifiers. Appropriate candidates will be given appointment times and on arrival will undergo the consent process for evaluation. A complete medical, social, psychiatric, and drug use history will be obtained. Subjects fulfilling general health ...

Phase N/A

The Effect of Smoking on Perception

Participation requires one 90-minute visit on the American University campus that involves completing questionnaires and computer tasks, watching a film, and smoking a cigarette. Participants earn 30 dollars.

Phase N/A

Role of CYP2B6 CYP3A4 and MDR1 in the Metabolic Clearance of Methadone

Methadone maintenance treatment (MMT) has been used to rehabilitate the opiate addict resulting in a higher quality of life for the patient as well as improving social and psychological functioning while reducing the overall cost to society. The maintenance dose of methadone is highly variable between patients, and drug-drug interactions ...

Phase

Developing Field Tools for Real-Time Assessment of Exposure to Psychosocial Stress and Drug Use in an Outpatient Treatment Population

Background. This protocol arose in response to NIH s Genes and Environment Initiative (GEI). There is no genetic component to this protocol (update: no genetics initially but added by amendment in February 2013); rather, the goal is to develop field-deployable measures of environmental influences (stressors, drug exposure, etc.) that can ...

Phase N/A

Linking Services to Patient Needs for Improved Patient Outcomes (CASPAR)

The proposed research study is directed at performing health services research in an estimated 15 community-based abstinence-oriented outpatient addiction treatment programs by developing ways of incorporating research-derived measures into standard clinical practice in the treatment of substance abuse clients. The primary goals are to use training and technology transfer to ...

Phase N/A

Contingency Management for Smoking in Substance Abusers

Substance abusers have a high prevalence and rate of smoking with little success in quitting, so stronger approaches are needed to encourage attempts to quit smoking. The aim of this study is to determine whether contingent reinforcement for smoking abstinence (CM), compared to noncontingent reinforcement (NR), increases the effectiveness of ...

Phase N/A

Computer-Assisted Stop-Smoking Program in Helping Doctors Counsel Patients Who Smoke Cigarettes

OBJECTIVES: - Test the hypothesis that the clinical decision support system will improve the rate at which physicians assist their patients with smoking cessation by providing information and recommendations on smoking cessation resources. - Assess whether exposure to information and recommendations facilitated by the smoking cessation-personal digital assistant (SC-PDA) will ...

Phase

Progesterone and Brain Imaging Study

The purpose of this study is to learn whether a sex hormone called progesterone is helpful in reducing cigarette smoking and craving for cigarettes. This study also includes brain imaging to measure possible effects of progesterone on certain neurochemicals. These neurochemicals are called gamma-aminobutyric acid (or GABA for short) and ...

Phase

Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer

PRIMARY OBJECTIVES: I. To determine the relationship between urinary deuterated ([D10]) phenanthrene tetraol (PheT) level, PheT:phenanthrols (HOPhe) ratio, and the presence of bronchoepithelial metaplasia and/or dysplasia in smokers who have undergone screening bronchoscopy at Roswell Park Cancer Institute (RPCI). OUTLINE Patients receive deuterated phenanthrene tetraol orally (PO). Urine samples are ...

Phase N/A