Search Medical Condition
Please enter condition
Please choose location from dropdown
Clear Trial Filters

Addictions Clinical Trials

A listing of Addictions medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (286) clinical trials

Project 3 Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders

This study will examine extended exposure to cigarettes varying in nicotine content among people with affective disorders. People with affective disorders are at an increased risk for smoking, nicotine dependence, and using high nicotine yield cigarettes and are also at significantly increased risk for smoking-related adverse health consequences. Studies testing ...

Phase

AXS-05 Phase II Trial on Smoking Behavior

This study aims to investigate the potential efficacy of a combination of two FDA-approved agents, sustained release (SR) Bupropion (BUP) and immediate release (IR) Dextromethorphan (DXM), for the purpose of smoking cessation treatment. DXM, a widely used over-the-counter cough suppressant, is a nicotine receptor antagonist. In fact, studies by Duke's ...

Phase

Smoking Cessation for People Living With HIV/AIDS

All research related activities will take place at the Tolan Park Medical Building located at 3901 Chrysler Service Dr, Detroit, 48201. Participants in Phase 1 will be randomized to one of two brief interventions based on standard of care guidelines (SoC): A) brief counseling and bupropion (SoC); or B) SoC ...

Phase N/A

Neural Mechanisms Associated With Risk of Smoking Relapse

Smoking is the greatest preventable cause of mortality and a significant economic burden. Even with the best available treatments, most smokers relapse within days or weeks after a quit attempt. Nicotine replacement therapy, the most widely used pharmacotherapy, yields end of treatment quit rates of <25% suggesting that managing nicotine ...

Phase N/A

Stage Ib Trial of mSMART for Smoking Cessation Medication Adherence

Poor medication adherence (a) results in poorer treatment outcome and (b) accounts for $100 to $290 billion in U.S. healthcare costs annually. Therefore, interventions that target medication adherence are increasingly crucial for patient care and cost-effectiveness. Mobile technologies such as smartphones are increasingly ubiquitous and affordable in the U.S., and ...

Phase N/A

Personalized Dosing of Nicotine Replacement (NRT to Effect)

A total of 500 smokers will be enrolled from two smoking cessation clinics to participate in this study. After 2 weeks of usual treatment with 21mg patch, participants who fail to quit smoking will be randomized to receive either escalating doses of active nicotine patches, or placebo patches, for 10 ...

Phase

Improving Treatment Outcomes for Prescription Opioid Dependence

Opioid dependence is a serious public health problem, particularly with the dramatic rise in prescription opioid abuse, but long-term opioid agonist maintenance with methadone or buprenorphine (BUP) may not be optimal for many prescription opioid abusers. Yet current opioid detoxification strategies are limited by high relapse rates and/or lack of ...

Phase

Teen Success Project

The overarching purpose of this study is to increase justice-involved youths' access to an evidence-based practice for substance abuse, specifically Contingency Management (CM). This randomized controlled trial will examine the effectiveness of using juvenile probation officers (JPOs) to deliver CM to youth (aged 12-17 years) on their caseloads. CM is ...

Phase N/A

Effects of Buprenorphine/Naloxone Dose on Experimental Stress Reactivity and Opioid Abstinence

This study will last for about 6-months. Participants will live on a residential unit for a minimum of 3 nights on 4 separate weeks (every other week). Participants will live on the residential unit for a total of 12 nights over this 7-week period. During that time, participants can't leave ...

Phase

Repetitive Transcranial Magnetic Stimulation in Patients With Opioid Use Disorders

Opioid use disorder (OUD) is prevalent and causes substantial health and social burdens. Although evidence have showed the effectiveness of opioid agonist maintenance therapy in OUD, high drop-out rate and the requirement of continuing use of opioid agonists are the major problems. Therefore, to develop novel treatment for OUD is ...

Phase N/A