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Heart Disease Clinical Trials

A listing of Heart Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (48) clinical trials

Identifying Vulnerable Plaques in Blood Vessels of the Heart Using a New Imaging Technique

Atherosclerosis is a condition in which deposits of fat, cholesterol, and other substances build up along the inner walls of arteries; these deposits are known as plaque. As plaque builds up, it increases the risk of heart attack. Previous autopsy studies have shown that vulnerable plaques, a type of atherosclerotic ...


A Pilot Study of Zavesca in Patients With Pompe Disease and Infusion Associated Reaction

This Study is designed to assess the effects of Zavesca as immunomodulatory therapy on anti-rhGAA immune responses in patients with Pompe disease, as well as their health and disease progression. Subjects will either receive Zavesca at 100 mg or 300 mg dosing levels during study participation (n=3 @ 100 mg ...


A Comparison of Two Sedation Techniques in Children Undergoing Transthoracic Echocardiography (TTE)

Currently there are two sedation methods used for children less than 24 months of age undergoing transthoracic echocardiography (TTE). One method provides sedation by mouth with the drug pentobarbital, The other provides sedation through the nose with the drug dexmedetomidine. The choice of which method is used is based on ...


Reoxygenation After Cardiac Arrest II (REOX II Study)

Specific Aim 1: Test if initiation of the rapid FiO2 optimization protocol following ROSC from cardiac arrest is associated with the degree of in vivo oxidative stress during the post-resuscitation phase of therapy. Approach: We will conduct a multicenter interventional study (FiO2 optimization protocol) of adult patients resuscitated from cardiac ...


Effect of Remote Ischemic Preconditioning in Patient Undergoing Cardiac Bypass Surgery

Ischemic heart disease (IHD) is currently the leading cause of morbidity and mortality in the developed world, and is set to become the leading cause of death in the world by the year 2020, according to the World Health Organisation. Patients with severe IHD that require coronary artery bypass graft ...


Different Platelet Activities Between Intracoronary and Peripheral Blood in Coronary Artery Disease Patients

Part A:A total of 30 CAD patients are recruited.All patients are on loading dose of 300 mg clopidogrel followed by a maintenance dose of 75 mg/d for at least 5 days and a loading dose of 300 mg aspirin followed by a maintenance dose of 100 mg/d for at least ...


Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome

This is an open label study, intended as a safety and efficacy assessment prior to a full comparator study. In this Phase I study, cells administered will be delivered in 6-10 intramyocardial injections that will be tested in 20 patients and 10 patients will be controls with a total of ...


Clinical Study of the BioVentrix Revivent TC for the Treatment of Ischemic Cardiomyopathy

The purpose of this prospective, single-armed, multi-center clinical trial is to further establish the feasibility of using the BioVentrix Revivent TC System for the treatment of left ventricular dysfunction in appropriate cohorts of humans suffering from heart failure. The objective of this study is to determine the safety and functionality ...


Transcoronary Infusion of Cardiac Progenitor Cells in Pediatric Dilated Cardiomyopathy

This trial consists of 2 studies. Seven consecutive patients will be enrolled to a phase 1a study to verify the procedural feasibility and safety, followed by a phase 1b study to randomly assign 24 patients in a 1:1 ratio to the CDC infusion group and the control arm.


Monitoring Medication Adherence in Left Ventricular Assist Device Recipients

The objectives are to assess the efficacy and safety of the Proteus Digital micro-sensor in an exploratory investigation among heart failure patients with LVADs. Medication adherence, specifically to anticoagulation is critically important in the post-implant period to maintain LVAD function and to decrease thromboembolic complications; however, commonly results in significant ...