Search Medical Condition
Please enter condition
Please choose location from dropdown
Clear Trial Filters
 

Heart Disease Clinical Trials

A listing of Heart Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (48) clinical trials

Study Evaluating the Safety Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491

The purpose of this Phase 1 study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of MYK-491 in patients with DCM and stable heart failure.

Phase

Identifying Vulnerable Plaques in Blood Vessels of the Heart Using a New Imaging Technique

Atherosclerosis is a condition in which deposits of fat, cholesterol, and other substances build up along the inner walls of arteries; these deposits are known as plaque. As plaque builds up, it increases the risk of heart attack. Previous autopsy studies have shown that vulnerable plaques, a type of atherosclerotic ...

Phase

A Pilot Study of Zavesca in Patients With Pompe Disease and Infusion Associated Reaction

This Study is designed to assess the effects of Zavesca as immunomodulatory therapy on anti-rhGAA immune responses in patients with Pompe disease, as well as their health and disease progression. Subjects will either receive Zavesca at 100 mg or 300 mg dosing levels during study participation (n=3 @ 100 mg ...

Phase

Radiation-Free Heart Catheterization Using MRI

Participants undergo general anesthesia, and vascular access is obtained in the x-ray catheterization lab. Next the participant is transferred into the MRI scanner where a focused MRI examination is performed. Catheters are then guided into the heart chambers using real-time MRI guidance to perform conventional cardiac catheterization steps. If time ...

Phase

A Comparison of Two Sedation Techniques in Children Undergoing Transthoracic Echocardiography (TTE)

Currently there are two sedation methods used for children less than 24 months of age undergoing transthoracic echocardiography (TTE). One method provides sedation by mouth with the drug pentobarbital, The other provides sedation through the nose with the drug dexmedetomidine. The choice of which method is used is based on ...

Phase

Reoxygenation After Cardiac Arrest II (REOX II Study)

Specific Aim 1: Test if initiation of the rapid FiO2 optimization protocol following ROSC from cardiac arrest is associated with the degree of in vivo oxidative stress during the post-resuscitation phase of therapy. Approach: We will conduct a multicenter interventional study (FiO2 optimization protocol) of adult patients resuscitated from cardiac ...

Phase

Effect of Remote Ischemic Preconditioning in Patient Undergoing Cardiac Bypass Surgery

Ischemic heart disease (IHD) is currently the leading cause of morbidity and mortality in the developed world, and is set to become the leading cause of death in the world by the year 2020, according to the World Health Organisation. Patients with severe IHD that require coronary artery bypass graft ...

Phase

Different Platelet Activities Between Intracoronary and Peripheral Blood in Coronary Artery Disease Patients

Part A:A total of 30 CAD patients are recruited.All patients are on loading dose of 300 mg clopidogrel followed by a maintenance dose of 75 mg/d for at least 5 days and a loading dose of 300 mg aspirin followed by a maintenance dose of 100 mg/d for at least ...

Phase

Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome

This is an open label study, intended as a safety and efficacy assessment prior to a full comparator study. In this Phase I study, cells administered will be delivered in 6-10 intramyocardial injections that will be tested in 20 patients and 10 patients will be controls with a total of ...

Phase

Clinical Study of the BioVentrix Revivent TC for the Treatment of Ischemic Cardiomyopathy

The purpose of this prospective, single-armed, multi-center clinical trial is to further establish the feasibility of using the BioVentrix Revivent TC System for the treatment of left ventricular dysfunction in appropriate cohorts of humans suffering from heart failure. The objective of this study is to determine the safety and functionality ...

Phase