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Heart Disease Clinical Trials

A listing of Heart Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (34) clinical trials

TIBOHCA: Safety Tolerability and Pharmacokinetics of 2-Iminobiotin (2-IB) After OHCA

Objective The primary objective of this study is to evaluate the short term safety and tolerability, and the pharmacokinetic properties of 2-IB when administered to adult patients after OHCA. Study design: A Phase 2, single-centre, open-label, dose-escalation intervention study. Study population: The study population will constitute of three cohorts of ...

Phase

Dietary Nitrates for Heart Failure (HF)

For all studies and sub-studies: All Subjects will be consented. B) All Subjects will give permission for the investigators to review their medical records. For the BRJ main study (acute dose BRJ intervention): After consenting to participate, subjects will be instructed to refrain from spitting or the use of an ...

Phase

Ruboxistaurin in New York Heart Failure Classification III-IV Patients

Ruboxistaurin is a drug initially developed for treatment of diabetic peripheral retinopathy. The proposed indication for ruboxistaurin in this study is the treatment of adult patients with New York Heart Failure Association (NYHA) Class III-IV heart failure. Ruboxistaurin is a protein kinase c-alpha (PKC-alpha) inhibitor and thus will produce an ...

Phase

Mesoblast Stem Cell Therapy for Patients With Single Ventricle and Borderline Left Ventricle

This is a prospective, single center, safety and feasibility, blinded, randomized trial to evaluate the use of MPCs in children with complex cardiac anatomy requiring surgical repair. Patients scheduled to undergo bidirectional Glenn (BDG) with future plans for LV recruitment, or patients with a history of BDG who are currently ...

Phase

Randomized Clinical Trial of MRI for Optimal CRT Outcomes

At baseline, patients will have CMR, echocardiography, and cardiopulmonary exercise testing. In patients randomized to CMR guidance for the CRT procedure, LV lead placement will be guided by the MRI information related to scar, activation and anatomy. Patients will have follow-up assessments at 6 and 12 months.

Phase

Cytokine Clearance With Cytoabsorbant Device During Cardiac Bypass

Investigators are planning a single center pilot randomized controlled trial to assess the potential of a Cytoadsorbant filter (Cytosorb, Germany) to remove cytokines from the blood during cardiac surgery. Investigators will screen all patients undergoing cardiac surgery and approach those deemed at risk of post surgical complications [ 1 among: ...

Phase

Inorganic NItrate and EXercise Performance in Heart Failure (iNIX-HF): Dose Response

Subjects will be patients with Heart Failure (HF). All subjects will be consented. All subjects will give permission for the investigators to review their medical records. After consenting to participate, subjects will be instructed to refrain from spitting or the use of an antibacterial mouthwash, antacids, proton pump inhibitors, or ...

Phase

Zepatier For Treatment Of Hepatitis C-Negative Patients Who Receive Heart Transplants From Hepatitis C-Positive Donors (HCV)

Open-labelled pilot clinical trial of Zepatier (MK-5172 and MK-8742/Grazoprevir + Elbasvir) in 10 HCV-negative subjects receiving a heart transplant from a HCV-positive donor. Eligible subjects will receive a heart transplant from a deceased-donor with genotype 1 or 4 HCV, and then will receive 12 weeks of Zepatier after heart transplantation ...

Phase

Influence of Catheter-based Renal Denervation in Diseases With Increased Sympathetic Activity

Inclusion Criteria Individual is 18 years of age. Individual agrees to have all procedures performed, and is competent and willing to provide written, informed consent to participate in the registry. Patient scheduled for renal sympathetic denervation using market-released device. Exclusion Criteria In the eyes of the treating physician, the renal ...

Phase

Accelerated Contrast-Enhanced High Resolution Whole Heart Cardiac MRI

Coronary artery disease (CAD) is the leading cause of death in the United States, even though significant efforts have been made in prevention and diagnosis. The clinical gold standard for diagnosis of CAD is catheter-based invasive x-ray angiography, performed more than a million times per year. Of these examinations, up ...

Phase