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Heart Disease Clinical Trials

A listing of Heart Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

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Found (59) clinical trials

Fructose is a sugar consumed in large amounts by Americans. It is rapidly taken up by the liver and changed into fats called triglycerides by a process called de novo lipogeneis. Over time, increased fat in the liver and bloodstream may increase the chances of diabetes and heart disease. As ...

Phase

A clinical trial seeking patients for a research study for the treatment of Hypertriglyceridemia

Phase

PHASE 2A, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE-DOSE, 2-PART STUDY TO ASSESS THE SAFETY, TOLERABILITY AND PHARMACOKINETIC RESPONSE AND EXPLORE THE PHARMACODYNAMIC RESPONSE FOLLOWING 4 WEEKS OF ONCE WEEKLY SUBCUTANEOUS INJECTIONS OF PB1046 IN ADULT SUBJECTS WITH STABLE HEART FAILUREWITH REDUCED EJECTION FRACTION (HFREF) (PART 1) AND IN SUBJECTS WITH CARDIAC DYSFUNCTION ...

Phase

A Study of Hemopure to Enhance Tissue Preservation During Cardiopulmonary Bypass Surgery

The primary objective is to determine the safety and feasibility of administering Hemopure® (HBOC-201) to reduce myocardial necrosis, as measured by CK-MB enzyme elevation, and enhance tissue preservation during cardiopulmonary bypass.

Phase

RESTORE-IT-Study of Rifalazil in Chlamydia Pneumoniae Seropositive Patients With a History of Atherosclerotic Disease

To evaluate the effect of treatment with rifalazil versus placebo taken once weekly for 12 weeks on carotid atherosclerotic disease progression in patients who test positive for Chlamydia pneumoniae. Measurements of the carotid artery wall (intima-media thickness) and plaque characteristics will be evaluated with high-resolution magnetic resonance imaging (MRI) and ...

Phase

Combined CABG and Stem-Cell Transplantation for Heart Failure

The prevalence of symptomatic heart failure in general population is up to 2% and the prevalence increases rapidly with age. Half of the patients with symptomatic heart failure will die within 4 years of diagnosis.The purpose of this study is to examine the effect of bone marrow-derived stem cell transplantation ...

Phase

Effect of 6R-BH4 Treatment in Coronary Artery Disease (OXBIO Study)

Decreased production of nitric oxide (NO) from the endothelium (the layer of cells that forms the lining of all blood vessels) has been shown to contribute to atherosclerosis. NO has multiple beneficial effects on vascular function. Endothelial function can be measured in humans via a number of methods, and endothelial ...

Phase

Niacin As Secondary Prevention Of Coronary Artery Disease (NASPOCAD)

Aim of the study is to show additional effects of the combined therapy of niacin and statins analyzing number and function of EPCs and other stem cell populations and adiponectin as well as hsCRP levels in patients with CAD.

Phase

Congestive Heart Failure Surgical Treatmment With Autologous Stem Cell Therapy

Primary target: determine the safety of introducing CD 34+ autologous progenitor cells (centrally grafted or mobilized in peripheral blood) in the myocardium of ischemic cardiac disease patients. Secondary target: determine clinical effects of grafted cells on remodeling pathology.

Phase

Surgical Manipulation of the Aorta and Cerebral Infarction

Stroke is one of the most devastating complications following coronary artery bypass grafting (CABG) with an overall incidence ranging from 2.0 % to 3.2 %. The presumed etiology for the majority of strokes after CABG is atheroembolism from the diseased aorta ascendens caused by surgical manipulation. Off-pump coronary artery bypass ...

Phase