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Malignant Melanoma Clinical Trials

A listing of Malignant Melanoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (227) clinical trials

Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma

OBJECTIVES: Primary - Compare the tumor-specific immune response, in terms of the number of gp100-specific cytotoxic T-lymphocytes, T-cell production of interferon gamma, or T-cell proliferation in response to in vitro exposure to gp100 and tumor lysate, in patients with stage III or IV melanoma treated with autologous dendritic cells (DC) ...

Phase

Collecting Tissue Samples From Patients With Melanocytic Nevi or Pigmented Lesions

OBJECTIVES: Primary - Obtain tissue from benign melanocytic nevi and LCMN for experimental study. - Refine culture and immortalization methods for melanocytes derived from melanocytic nevi that permits in vitro expansion of these cells for functional study. - Correlate clinical and dermoscopic observations of primary melanoma with histopathology to establish ...

Phase N/A

Lymphodepletion Plus Adoptive Cell Transfer With or Without Dendritic Cell Immunization in Patients With Metastatic Melanoma

Leptomeningeal Disease: (Cohort D): Study Visits: You are expected to stay in the Houston area for at least 21 days in order to take part in this study. During this study, you will have the following tests and procedures: - You will have an MRI of the complete spine and ...

Phase

Family Study of Melanoma in Italy

To date 557 subjects, including cases of melanoma and unaffected relatives, have been recruited in the family study of melanoma at the Bufalini Hospital, Cesena, Italy, University ofl'Aquila, L'Aquila, Italy, and the Istituto Valenciano de Oncologia, Valencia, Spain. Clinical characteristics of melanoma in the families studied were similar to those ...

Phase N/A

Characterization of the Melanoma-Specific Immune Response

The aim of the study is to in-vitro characterize and expand T cells specific for melanoma-derived antigens. Peripheral blood with be collected from 20 volunteers with biopsy proven melanoma and 10 age matched controls. Blood will be collected prior to the initiation of chemotherapy. There will be no more than ...

Phase

Investigate the Diagnostic Value and Possibilities of OCT in Non-Melanoma Skin Cancer.

Optimal management of skin malignancies relies on early and accurate diagnosis. The reference standard in skin cancer is biopsy and histopathological assessment from a clinical suspicious skin lesion. The clinical diagnosis of skin cancer has sensitivity ranging from 50% to 90 % and specificity around 70% to 80% depending on ...

Phase

Melanoma Inhibitory Activity (MIA): A Serological Marker for Metastatic Uveal Melanoma

Serum is taken from each melanoma patient at every follow up after signed concent. With ELISA the marker MIA is evaluated. An increase of MIA serum level will lead to search for metastasis by oncologists.

Phase N/A

Study of Families With Melanoma

OBJECTIVES: Primary - Determine what lifestyle factors and which genes govern relapse from melanoma. Secondary - Compare sun exposure and genes that cause melanoma in patients with melanoma vs healthy participants. - Assess how unusual moles relate to sun exposure and genes that cause melanoma. OUTLINE: This is a multicenter, ...

Phase N/A

Identifying Gene Mutations in Patients With Melanoma and in Families With a History of Hereditary Melanoma

OBJECTIVES: - Determine the incidence and etiologic significance of variants of known melanoma susceptibility genes (MSGs) in families with multiple cases of melanoma. - Determine the proportion of multiple-case families that are explained by high-penetrance mutations in known MSGs. - Determine the proportion of multiple-case families that are explained by ...

Phase N/A

Sorafenib Tamoxifen and Cisplatin in Treating Patients With High-Risk Stage III Melanoma

OBJECTIVES: - Compare relapse-free and overall survival of patients with high-risk stage III melanoma receiving adjuvant sorafenib tosylate, tamoxifen citrate, and cisplatin vs historical data from patients treated with tamoxifen citrate and cisplatin. - Compare the toxicity of these regimens in these patients. OUTLINE: This is a pilot study. Patients ...

Phase