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Malignant Melanoma Clinical Trials

A listing of Malignant Melanoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (225) clinical trials

Chemotherapy and Total-Body Irradiation Followed By Laboratory-Treated Autologous Lymphocytes Aldesleukin and Vaccine Therapy in Treating Patients With Metastatic Melanoma

OBJECTIVES: Primary - Determine if the administration of anti-gp100:154-162 and anti-MART-1:27-35 T-cell receptor (TCR) gene-engineered peripheral blood lymphocytes (PBL), high-dose aldesleukin, and gp100:154-162 or MART-1:26-35(27L) peptide vaccination following a chemoradiation lymphodepleting preparative regimen results in complete clinical tumor regression in patients with metastatic melanoma (closed as of 09/21/09). - Determine ...


Selective HDAC6 Inhibitor ACY-241 in Combination With Ipilimumab and Nivolumab

This is a Phase 1b, open-label, dose-escalation cohort study. The study will consist of a dose escalation assessment of the safety and tolerability of ACY-241 administered concurrently in combination with ipilimumab and nivolumab to patients with advanced melanoma. Treatment will be divided into induction and maintenance phases. Determine the safety, ...


Neoadjuvant L19IL2/L19TNF- Pivotal Study

Phase III, open-label, randomized, controlled multi-center study. In the study, 214 patients will be enrolled and parallel assigned (via randomization system) in a 1:1 fashion to one of two different arms: ARM 1: Patients in Arm 1 will receive multiple intratumoral administrations into all injectable cutaneous, subcutaneous, and nodal tumors ...


Ipilimumab and Nivolumab in Leptomeningeal Metastases From Melanoma

This research study is a Phase II clinical trial. Researchers hope to study the effects of the combination of Nivolumab and Ipilimumab. Many cancers use specific pathways (such as PD-1/PD-L1 and CTLA-4) to evade the body's immune system. Nivolumab and ipilimumab work by blocking the PD-1/PD-L1 and CTLA-4 pathways and ...


Study of ASN003 in Subjects With Advanced Solid Tumors

The study will be conducted in two parts. Part A is a dose escalation study to determine a safe and tolerable dose of ASN003 for subjects with advanced solid tumors. Part A will also characterize the pharmacokinetics and pharmacodynamics of ASN003 through blood sampling and optional biopsies.. Part B will ...


Study of DS-8273a With Nivolumab in Unresectable Stage III or Stage IV Melanoma

Principal investigator hypothesize that TRAIL D5 antibody DS-8273a administered in combination with nivolumab will be well tolerated and that the addition of DS-8273a will augment the clinical efficacy of nivolumab.