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Malignant Melanoma Clinical Trials

A listing of Malignant Melanoma medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (61) clinical trials

The purpose of this study is to assess the safety, tolerability, and efficacy when combining MK-3475 and INCB024360 in subjects with certain cancers. This study will be conducted in 2 phases, Phase 1 (closed) and Phase 2 (open to enrollment)

Phase N/A

The purpose of this study is to assess the safety, tolerability, and efficacy when combining INCB024360 and Nivolumab in subjects with certain cancers. This study will be conducted in 2 phases, Phase 1 (closed) and Phase 2 (open to enrollment)

Phase N/A

This is an open label, non-randomized, multi-center study. The primary purpose of the study is to evaluate the safety, tolerability and efficacy of Epacadostat and Durvalumab when given in combination in patients with Selected Advanced Solid Tumors.

Phase N/A

Studying Tumor Tissue Samples From Patients With Melanoma Who Have Undergone Sentinel Lymph Node Biopsy

OBJECTIVES: - Develop a predictive model for sentinel lymph node biopsy positivity in patients with melanoma who have undergone sentinel lymph node biopsy. - Develop a survival model for relapse based on sentinel lymph node biopsy positivity. - Assess the genetic determinants in primary melanomas that predict a metastatic phenotype ...

Phase N/A

Effects of Monoclonal Antibody GC1008 in Blood Samples From Patients With Unresectable Locally Advanced or Metastatic Kidney Cancer or Malignant Melanoma Treated on Clinical Trial NCI-06-C-0200

OBJECTIVES: - To determine whether treatment with human anti-TGF-beta monoclonal antibody GC1008 results in a detectable decrease in phospho-Smad2 levels in freshly collected blood samples from patients with unresectable locally advanced or metastatic renal cell carcinoma or malignant melanoma treated on clinical trial NCI-06-C-0200. - To determine whether the decrease ...

Phase N/A

Follow Up Protocol for Subjects Previously Enrolled in NCI Surgery Branch Studies

BACKGROUND: - Patients receiving care at the NIH Clinical Center are required to be enrolled in a clinical protocol - Following participation in a treatment protocol, it may be in the best interest of the patient to continue to be followed at the Clinical Center - The NCI Surgery Branch ...

Phase N/A

In Vivo Real-time Detection of Circulating Melanoma Cells

Study Population: Approximately 80 subjects will be consented in order to achieve an enrollment goal of 75 subjects at this institution in three cohorts as follows: 1. Cohort #1 will consist of fifteen healthy control subjects, ten of whom will be Caucasian and five of whom will be African-American. Subjects ...

Phase N/A

Examination of Clinical and Laboratory Abnormalities in Patients With Defective DNA Repair: Xeroderma Pigmentosum Cockayne Syndrome or Trichothiodystrophy

Four rare genetic diseases, xeroderma pigmentosum (XP), Cockayne syndrome (CS), the XP/CS complex and trichothiodystrophy (TTD) have defective DNA excision repair although only XP has increased cancer susceptibility. We plan to perform careful clinical examination of selected patients with XP, XP/CS, CS, or TTD and follow their clinical course. We ...

Phase N/A

Evaluation for NCI Surgery Branch Clinical Studies

Background: Potential research candidates undergo thorough screening including laboratory tests, scans, x-rays and review of pathology slides to determine initial eligibility for Surgery Branch research protocols. Objectives: To permit evaluation of patients referred to the NCI Surgery Branch in order to identify individuals who will be suitable candidates for Surgery ...

Phase N/A