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Ovarian Cancer Clinical Trials

A listing of Ovarian Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (10) clinical trials

Circulating Tumor DNA Exposure in Peripheral Blood

This prospective, multi-center, feasibility study represents a feasibility study to determine the potential of circulating tumor DNA exposure in peripheral blood using a novel process in a sample of patients with different types of malignant organ tumors and a control cohort without malignant disease. The study applies a new process ...

Phase N/A

Debulking Surgery in Ovarian Cancer

The objective of this study is to implement, evaluate, and further investigate the role of minimally invasive surgery in patients undergoing interval debulking following neoadjuvant chemotherapy in patients with advanced ovarian cancer. Primary Objective: Prospectively evaluate the feasibility and safety of the minimally invasive interval debulking approach Secondary Objective(s) Identify ...

Phase N/A

A Phase 3 Randomized Double-blind Placebo-controlled Multicenter Trial of Maintenance Treatment With BGB-290 Versus Placebo in Patients With Platinum-sensitive Recurrent Ovarian Cancer

To evaluate the efficacy, safety tolerability of maintenance therapy with BGB-290 versus placebo in Chinese patients with recurrent ovarian cancer who achieved a complete response (CR) or partial response (PR) after platinum-based chemotherapy

Phase

Restrictive or Individualized Goal-Directed Fluid Replacement Strategy in Ovarian Cancer Cytoreductive Surgery

Aims & objectives: The purpose of the study is to test the hypothesis that intra-operative SVV-guided fluid optimization during ovarian cancer cytoreductive surgery - Reduces the postoperative length of hospital stay. GDT is more cost-effective. GDT will be more beneficial in cases of PDS compared to IDS. GDT reduces postoperative ...

Phase

A Safety Pharmacokinetic Pharmacodynamic and Anti-Tumor Study of PF-06873600 as a Single Agent and in Combination With Endocrine Therapy

This is a Phase 1/2a, open-label, multi-center, non-randomized, multiple dose, safety, tolerability, pharmacokinetic, and pharmacodynamic study of PF-06873600 administered as a single agent in sequential dose levels and then in combination with endocrine therapy. In Part 1A, successive cohorts of patients will receive escalating doses of PF-06873600 and then in ...

Phase

BrUOG 354 Nivolumab +/- Ipilimumab for Ovarian and Extra-renal Clear Cell Carcinomas

Preclinical and early-phase clinical data suggest that immune modulation represents a treatment strategy that is worthy of further investigation in relapsed epithelial ovarian cancer. One method by which tumor cells may evade immune surveillance is by activation of the programmed cell death (PD-1) pathway, mediated by expression of PD-1 on ...

Phase

Study to Evaluate Safety PK PD Immunogenicity & Antitumor Activity of MSC-1 in Patients With Adv Solid Tumors

MSC-1 is a first-in-class, humanized monoclonal antibody (IgG1) which binds to the immunosuppressive human cytokine Leukemia Inhibitory Factor (LIF), and is intended to treat adult patients with advanced solid tumors. LIF is a pleiotropic cytokine involved in many physiological and pathological processes including the promotion of an immunosuppressive environment. In ...

Phase

Molecular Imaging and Spectroscopy With Stable Isotopes in Oncology and Neurology

This is a single-centre prospective physiological study. Participants will be recruited through MDTs and clinics. Baseline screening blood tests will be performed. Baseline MRI will be undertaken to identify lesions to be studied. This will be followed by hyperpolarised carbon-13 MRSI after the injection of hyperpolarised 13C-pyruvate. Scanning with 18F-FDG ...

Phase N/A

A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.

This is a phase I/II open-label, multicenter study to evaluate the safety, tolerability, pharmacokinetics (PK) and antitumor activity of MEDI4736 in combination with olaparib in patients with advanced solid tumors, selected based on a rationale for response to olaparib. Patients will be poly (adenosine diphosphate-ribose) polymerase (PARP)-inhibitor and immunotherapy (IMT)-nave ...

Phase

Phase 2 Study of Pembrolizumab DPX-Survivac Vaccine and Cyclophosphamide in Advanced Ovarian Primary Peritoneal or Fallopian Tube Cancer

This study has two phases: a dose escalation phase and a dose expansion phase. For the dose escalation part, groups of participants will receive one of two dose levels of study drugs to determine the best dose level for further testing. Once the best dose level is found, additional participant ...

Phase