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Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (312) clinical trials

Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

A major component of understanding the pathogenesis of mood and anxiety disorders is expected to involve elucidation of abnormalities of brain structure and function associated with these conditions. Historically, post-mortem histopathological and neurochemical assessments constituted the primary methods for investigating abnormalities of brain structure and function in psychiatric disorders. However, ...

Phase N/A

A Double-Blind Sham Controlled Trial of rTMS in Treatment Resistant Major Depression

Justification for project TRD is clearly a major health issue - depression is common, results in marked morbidity and mortality and a large percentage of patients do not respond to, or cannot tolerate standard treatment. The development of new treatments for this condition is undoubtedly required. International efforts are underway ...

Phase N/A

Prevention of Depression With Omega-3 Fatty Acids in Chronic Carriers of Hepatitis C Treated With Interferon Alpha.

Omega-3 fatty acids are known as an alternative treatment for different conditions, including mental conditions, such as depression. We assume that combining omega-3 with the treatment by interferon alpha may prevent the development of depression, which is quite a common side effect of the interferon alpha.


Reboxetine Treatment in Depressed Children and Adolescents an 8-Week Open Study

Introduction: Depression is a prevalent disorder involving 3% of children and 8% of adolescents (Birmaher et al, 1996). Reboxetine, a highly selective norepinephrine reuptake inhibitor, is a representative of a fairly new class of antidepressant agents with specificity for the noradrenergic system (Kasper et al., 2000). Long-term clinical trials of ...


rTMS in the Treatment of Bipolar Depression

Bipolar affective disorder is a serious mental illness with significant mortality and morbidity [1]. Some estimates of prevalence in Western populations are as high as 6.4% [2]. The depressive aspect of bipolar disorder is often overlooked, possibly due to its less dramatic nature, despite its significant impact on the lives ...


Treatment Resistant Depression and Obstructive Sleep Apnea Effect of Continuous Positive Airway Pressure (CPAP)

Primary objective: What is the effect on mood and anxiety symptoms of adding CPAP to the psychiatric treatment of patients with TRD and associated OSA? Secondary objectives: 1. How common is co-morbid OSA in patients with treatment resistant unipolar depression referred to a tertiary Mood Disorders Clinic? 2. Is there ...

Phase N/A

Morbidity and Mortality Among Dialysis Patients After Treatment for Depression

Morbidity and Mortality among Dialysis Patients after Treating Depression Objectives Our investigation has two objectives: 1. To assess whether treatment and recovery from depression decreases adverse clinical events in chronic hemodialysis patients. Significant morbidity is associated with depression in dialysis patients, but subsequent impact on outcome after treatment of depression ...


Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder

Disturbance of sleep is a prominent symptom in depressive disorders. Alterations of sleep patterns in depressed patients include insomnia, frequent awakenings, early wake-up and non-refreshing sleep. Polysomnographic recordings have confirmed these reports, reporting reduced latency of the first REM episode of the night, with decreased density of rapid eye movements, ...


Myths About Bipolar Affective Disorder: The Role of Structured Group Psychoeducation Therapy

Methods: Effect psychoeducation: Study population - 30 patients diagnosed with BAD treated in the outpatient clinic, in a state of remission will be evaluated with the Hamilton Rating Scale for Depression, Young Mania Rating Scale, and will then participate in 7 weekly sessions of brief structured psycho education therapy Control ...

Phase N/A

Screening Questionnaire for Depression

Depression is common in primary care and general medical settings, but is often unrecognized and untreated by physicians working in those settings. The Patient Health Questionnaire for depression (PHQ-9) is well validated and widely used screening instrument.

Phase N/A