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Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (162) clinical trials

A clinical research study evaluating an investigational drug for its safety and effectiveness in the treatment of Major Depressive Disorder Eligibility Criteria: Be 18 to 65 years old Diagnosed with Major Depressive Disorder Not getting adequate results with current antidepressant therapy Other Details: Eligible participants will receive investigational drug as ...

Phase N/A

Pilot Study of a Self-help Intervention for Depression in Patients With a Chronic Disease

Depressed mood is common in patients with chronic disease and physical disability. It adversely affects quality of life, adherence to treatment and clinical outcome. Depression is expensive to the person, their family, employers and society. Recent developments in the UK General Practitioners' Contract mean that patients with two chronic diseases ...

Phase N/A

Improving Psychological Wellness After Acquired Brain Injury

Each year, approximately 50,000 Canadians sustain an acquired brain injury (ABI) with 16,000 of those individuals living in Ontario. Individuals with ABI not only suffer significant cognitive and motor impairments, but they often experience debilitating emotional distress. Emotional distress uniquely contributes to poorer functional outcomes and decreased quality of life. ...

Phase N/A

Brain Derived Neurotrophic Factor as a Predictor of Response to Treatment in Bipolar Depression and Mania: 16-weeks Follow-up With Quetiapine XR

There is sound evidence that quetiapine is effective in the treatment of manic and depressive episodes associated with Bipolar Disorder (BD) (Yatham et al 2006). However, even with the development of effective new treatment options, not all patients respond to treatments available. Biological markers have been investigated as predictors of ...

Phase

Dialogical and Narrative Processes in Couple Therapy for Depression

In each of these research centres qualified family therapists will conduct the couple therapy in case of depressed patients in a team of two therapists. To be a responsible therapist in this study the minimum criterion is three years specialist- level family therapy training and thus a qualification as psychotherapist ...

Phase

Desvenlafaxine Succinate (DVS) for Major Depressive Disorder (MDD) in Midlife Men and Women

Major Depressive Disorder (MDD) has been associated with morphological changes in the brain and changes in key brain areas. Studies have shown that antidepressant use may promote the normalization of these areas. Moreover, midlife men and women appear to be at greater risk for developing major depressive episodes. In women, ...

Phase

Duloxetine for Major Depression in Peri-/Postmenopausal Women

Women approaching menopause and during the post-menopausal years appear to be at greater risk for developing major depressive episodes. Moreover, this period in life has been associated with significant functional impairment due to the presence/severity of vasomotor symptoms (hot flashes, night sweats), cognitive complaints, and poorer quality of life. In ...

Phase

Berlin Magnetic Seizure Therapy Depression Trial 01

This treatment pilot study will investigate clinical efficacy and adverse effects of magnetic seizure therapy (MST) in patients currently experiencing a unipolar or bipolar depressive episode. The investigators will perform add-on tests to assess clinical and cognitive response to treatment. It is hypothesized that MST will have an antidepressant efficacy ...

Phase

Lithium and Standard Therapy in Resistant Depression

Inclusion criteria: 1. Diagnosis of major depression (clinical diagnosis, guided by DSM-IV criteria). 2. History of attempted suicide or deliberate self-harm in the previous 12 months. 3. Inadequate response to at least two antidepressants given sequentially at an adequate dose for an adequate time for the current depressive episode. 4. ...

Phase

Asenapine for Bipolar Depression

86 patients with an episode of major depression associated with bipolar disorder, type I will be recruited by two sites for the study over fifteen months. Medication will be administered in a double-blind manner. Patients will receive asenapine (or placebo) beginning on day 0 at 5 mg bid. Dose may ...

Phase