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Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (21) clinical trials

Still feeling symptoms of depression after having taken a prescription antidepressant? If so, participating in our medical research study of an investigational drug may be an option for you.

Phase

Cannabidiol as an Adjunctive Treatment for Bipolar Depression

Depressive symptoms are associated with significant psychosocial impairment. However, current treatments of bipolar depression are only partially effective. Cannabidiol is a natural component of cannabis without psychotomimetic or addictive properties. Cannabidiol has been shown to produce therapeutic effects including anticonvulsive, anxiolytic, antipsychotic and neuroprotective effects. The investigators hypothesize that treatment ...

Phase

NRX101 Glx Biomarker Validation Study

Subnormal level of Glutamate+Glutamine (Glx) in the Anterior Cingulate Cortex (ACC) of the brain has been associated with depression and PTSD. Similarly, interventions that increase the level of Glx in the brain, specifically electroconvulsive therapy (ECT) and intravenous ketamine infusion have been associated with a rapid decrease in depression and ...

Phase

Study of Neural Responses Induced by Antidepressant Effects

Over the past decade, neuroimaging tools have rapidly advanced the field of neural biomarkers of treatment response in depression. Still, despite obvious scientific progress in this field, the ability to implement neuroimaging biomarkers of antidepressant treatment response in clinical trial settings is lacking. In order to objectively asses the neural ...

Phase

Lithium for Suicidal Behavior in Mood Disorders

Objective: To test the hypothesis that lithium augmentation of enhanced usual care will reduce the rate of repeated episodes of suicidal self-directed violence (repeated suicide attempts, interrupted attempts, hospitalizations specifically to prevent suicide, and deaths from suicide) in participants with bipolar disorder or depression who have survived a recent event. ...

Phase

Study on the Use of Low Dose Ketamine After Gastric Bypass and Gastrectomy

This is a randomized, double-blind, placebo-controlled, two-arm parallel, single-center study. One hundred subjects (50 in each arm) will be enrolled. Subjects, between the ages 18 and 65, undergoing laparoscopic gastric bypass or sleeve gastrectomy will be recruited and consented during the preadmission visit prior to surgery. Eligible subjects will be ...

Phase

Transcranial Direct Current Stimulation (tDCS) as an add-on Therapy for Treatment of Major Depressive Disorder. (DEPTDCS2014)

The aim is to investigate the safety and effectiveness of transcranial Direct Current Stimulation (tDCS) in patients with moderate to severe major depression compared to patients treated with conventional therapy. The tDCS will be used as add-on to conventional therapy. This is a randomized 2-arm parallel, double blind study comparing ...

Phase

Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Personalized Approach

This study will evaluate the anti-inflammatory effects and antidepressant efficacy and tolerability of EPA versus placebo in the treatment of MDD. The study design is a randomized, placebo-controlled, double-blind parallel-group dose-finding 12 week outpatient clinical trial. The study population will consist of outpatients who are overweight and suffer from MDD, ...

Phase

Ketamine as an Alternative Treatment to ECT in Major Depressive Disorder

In line with the PICO model, patient selection and procedures for experimental and control treatments and outcome measures are rigorously defined. Inpatients, aged 18-85, diagnosed with major depressive disorder (MDD, according to DSM-IV), that have been offered and have accepted ECT, are eligible to participate. Patients must be proficient in ...

Phase

Early Intervention for Youth at Risk for Bipolar Disorder

Children who are at high risk for developing bipolar disorder (BD) often are showing significant mood swings or depression well before they develop the full disorder. Often, these children have one or more parents who have bipolar disorder. In addition to brief episodes of lethargic depression and mania or hypomania ...

Phase