Search Medical Condition
Please enter condition
Please choose location from dropdown
Clear Trial Filters
 

Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (64) clinical trials

The purpose of this study is to evaluate the efficacy of vortioxetine treatment period in the prevention of relapse in participants with major depressive disorder (MDD).

Phase

This study is a randomized, double-blind, placebo-controlled study to evaluate 3 fixed doses (5, 10, and 20 mg oral tablets) of vortioxetine once daily in the prevention of relapse in adult subjects with major depressive disorder (MDD) who have responded to acute treatment with vortioxetine.

Phase

A clinical study designed to collect information on the safety and efficacy of an anti-depressant to treat depression, OCD, or anxiety with or without CBT therapy.

Phase

Can Genetic Testing help you find the right medication for your depression? One of the worst side effects of a psychotropic medication is when it just doesn't work. Selecting the medication that's right for someone is often a challenge. But finding the appropriate medication may help avoid additional challenges that ...

Phase

Advancing Personalized Antidepressant Treatment Using PET/MRI

Aim 1: Determine a Pretreatment Marker of SSRI Effectiveness Using PET. With the goal of reducing MDD burden, many studies have assessed the utility of FDG-PET in antidepressant treatment prediction. However, due to the limitations listed above, there is no consensus on which brain regions are predictive of treatment efficacy. ...

Phase

Treating Caregiver Depression to Improve Childhood Asthma: Impact and Mediators

Caregiver will be consented for his/her and the child's participation. The child will assent to participate before study procedures begin. The proposed study will last 52 weeks and consist of study visits every 4 weeks (14 visits total). Screening (roughly 5 mins): 2 item Self-Report Screening Tool for Depression (2-SRSD) ...

Phase

ECT With Ketamine Anesthesia vs High Intensity Ketamine With ECT Rescue for Treatment-Resistant Depression

Major depressive disorder (MDD) is a common psychiatric illness that will affect at least 15% of the population. The burden of MDD is staggering, considered by the World Health Organization to be the leading cause of disability in developed countries for people aged 15-44. Oral antidepressant therapy for MDD is ...

Phase

Patient Stratification and Treatment Response Prediction in Neuropharmacotherapy Using Hybrid Positron Emmission Tomography/Magnetic Resconance Imaging (PET/MR)

Selective serotonin reuptake inhibitors (SSRIs) raise serotonin (5-HT) in the synaptic cleft and are the current first line of pharmacological antidepressive treatment. Yet, there is a missing link between this first molecular step in their mechanism of action and observed clinical improvement. We have determined to establish a framework combining ...

Phase

The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder

Vortioxetine is a novel antidepressant with hypothetical multimodal mechanism of action. It is thought to work through a combination of multiple pharmacological modes of action: 5-HT (hydroxytryptamine, or serotonin) reuptake inhibition, 5-HT3 (hydroxytryptamine, or serotonin) and 5-HT7 (hydroxytryptamine, or serotonin) receptor antagonism, 5-HT1A (hydroxytryptamine, or serotonin) receptor agonism, and 5-HT1B ...

Phase

A Pilot Study Investigating the Efficacy of Minocycline and N-Acetyl Cysteine for Bipolar Depression

The investigators are doing this research study to find out if minocycline alone, N-acetyl cysteine (NAC) alone, or the combination of minocycline and NAC can help people with bipolar depression when added to lithium. The investigators also want to find out if minocycline, NAC, and the combination of minocycline and ...

Phase