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Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (33) clinical trials

Can Genetic Testing help you find the right medication for your depression? One of the worst side effects of a psychotropic medication is when it just doesn't work. Selecting the medication that's right for someone is often a challenge. But finding the appropriate medication may help avoid additional challenges that ...

Phase

A clinical study designed to collect information on the safety and efficacy of an anti-depressant to treat depression, OCD, or anxiety with or without CBT therapy.

Phase

This study is a randomized, double-blind, placebo-controlled study to evaluate 3 fixed doses (5, 10, and 20 mg oral tablets) of vortioxetine once daily in the prevention of relapse in adult subjects with major depressive disorder (MDD) who have responded to acute treatment with vortioxetine.

Phase

Major Depressive Disorder (MDD) can be a long-term illness, with many patients experiencing relapse. Clinical Trials of Texas, Inc. is currently enrolling patients for a new study to evaluate the relapse prevention effects of an FDA-approved study medication on patients with MDD. Those that participate will receive testing, examinations, study ...

Phase

The purpose of this study is to evaluate the efficacy of vortioxetine treatment period in the prevention of relapse in participants with major depressive disorder (MDD).

Phase

Duloxetine for Major Depression in Peri-/Postmenopausal Women

Women approaching menopause and during the post-menopausal years appear to be at greater risk for developing major depressive episodes. Moreover, this period in life has been associated with significant functional impairment due to the presence/severity of vasomotor symptoms (hot flashes, night sweats), cognitive complaints, and poorer quality of life. In ...

Phase

Lithium and Standard Therapy in Resistant Depression

Inclusion criteria: 1. Diagnosis of major depression (clinical diagnosis, guided by DSM-IV criteria). 2. History of attempted suicide or deliberate self-harm in the previous 12 months. 3. Inadequate response to at least two antidepressants given sequentially at an adequate dose for an adequate time for the current depressive episode. 4. ...

Phase

Cytochrome P450-2D6 Screening Among Elderly Using Antidepressants (CYSCE)

This study is a multicenter randomized controlled trial in which psychiatric elderly care centers participate in the Netherlands. Deviating genotypes are expected to be found in ~30% of the population, therefore the study consist out of two parts. First a basic study in which ~750 patients, starting with nortriptyline or ...

Phase

A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar Depression.

Most pharmacologic treatments of depression rely on serotonergic and/or noradrenergic mechanisms. Yet, evidence both from animal studies and from human trials suggests a role for dopaminergic pathways and particularly for dopamine D2-like receptors in the treatment of depression. In recent years, two new selective agonists of dopamine D2-like receptors have ...

Phase

The Effect of Duloxetine on Interoceptive Awareness

This study focuses on possible mechanism mediating duloxetine effects on painful physical symptoms in patients suffering from MDD. Our hypothesis is based on the assump¬tion of dual impairment of the somatosensory system in these patients. Hypalgesia to phasic experimental pain may be due to diminished spinal and brainstem transmission. Hyperalgesia ...

Phase