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Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (83) clinical trials

To assess, in subjects with MDD who have had an inadequate response to current antidepressant therapy with an SSRI or SNRI, the efficacy of flexibly dosed JNJ-42847922 (20 mg or 40 mg) compared to flexibly dosed quetiapine XR (150 mg or 300 mg) as adjunctive therapy to an antidepressant drug ...

Phase

This research study examines the safety and effectiveness of an investigational drug in adult subjects with major depressive disorder who have responded inadequately to antidepressant therapy. This study is approximately 12 weeks.  The first visit will consist of a physical exam, blood draw, ECG, urine drug screen and psychiatric assessments. 

Phase

The primary purpose of the Clarity study is to determine if the investigational medication, pimavanserin, is effective versus placebo in patients with Major Depressive Disorder (MDD) who are not receiving adequate response to their current medication treatment. After an initial 8-21 day screening period, qualified study participants will enter a ...

Phase

The purpose of this study is to evaluate the efficacy of sirukumab as adjunctive treatment to antidepressant therapy, where sirukumab is measured over a 12 week study period for treatment of depression symptoms.

Phase

A clinical research study to evaluate the safety, effectiveness and tolerability of an investigational drug for individuals with Major Depressive Disorder.

Phase

This study is a multicenter, randomized, double-blind (with a single-blind placebo lead-in), placebo-controlled, parallel-group, fixed-dose, 3-week study in participants with MDD. The study will include a total of 10 visits and will be approximately 5 weeks in duration.

Phase

A Study to Evaluate the Efficacy Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant Depression

The purpose of this study is to evaluate the efficacy of fixed dosed intranasal esketamine compared to intranasal placebo, as an add-on to an oral antidepressant in Japanese participants with treatment-resistant depression (TRD), in improving depressive symptoms.

Phase

Synchronized Transcranial Magnetic Stimulation for PTSD

Posttraumatic stress disorder (PTSD) is a highly prevalent psychiatric disorder associated with high degrees of comorbidity (e.g., major depressive disorder), poor quality of life, and significant social and occupational dysfunction. Currently available evidence-based pharmacological and psychological treatments for PTSD have only modest efficacy, and thus further research is necessary to ...

Phase

Ebselen as an add-on Treatment in Hypo/Mania

Ebselen, a new drug for mania Bipolar disorder, formerly known as manic depression, is a condition that affects mood, which can swing from one extreme to another. Typically, there will be periods of: Depression - very low mood and energy levels Mania or hypomania (less severe) - very high mood ...

Phase