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Depression Clinical Trials

A listing of Depression medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (85) clinical trials

The purpose of this study is to evaluate the efficacy of sirukumab as adjunctive treatment to antidepressant therapy, where sirukumab is measured over a 12 week study period for treatment of depression symptoms.

Phase

This study is a randomized, double-blind, active-controlled, Phase 2 trial, consisting of a screening period of up to 4 weeks, and a 6-week treatment period.

Phase

This study will assess the effectiveness of pimavanserin when given along with a selective serotonin reuptake inhibitor/selective norepinephrine reuptake inhibitor (SSRI/SNRI) for depression in adults with Parkinson’s disease.

Phase

The purpose of this study is to see if an investigational medicine in addition to taking a current active anti-depressant is effective and safe for patients with Major Depressive Disorder.  

Phase

To assess, in subjects with MDD who have had an inadequate response to current antidepressant therapy with an SSRI or SNRI, the efficacy of flexibly dosed JNJ-42847922 (20 mg or 40 mg) compared to flexibly dosed quetiapine XR (150 mg or 300 mg) as adjunctive therapy to an antidepressant drug ...

Phase

This study is a multicenter, randomized, double-blind (with a single-blind placebo lead-in), placebo-controlled, parallel-group, fixed-dose, 3-week study in participants with MDD. The study will include a total of 10 visits and will be approximately 5 weeks in duration.

Phase

An Adaptive Algorithm-Based Approach to Treatment for Adolescent Depression

The purpose of this study is to evaluate the effectiveness of two adaptive treatment strategies (ATSs) for adolescent depression. The ATSs include delivery of an evidence-based psychotherapy (interpersonal psychotherapy for depressed adolescents, IPT-A), systematic symptom monitoring, and an empirically-derived algorithm that specifies whether, when, and how to augment IPT-A. Two ...

Phase

Testing the Ability of JNJ-18038683 to Improve Cognition and Reduce Depressive Symptoms in Stable Bipolar Patients

Most, but not all, patients with bipolar disorder (BPD) have clinically significant cognitive impairment. Impairment is present in both the manic and depressed phases of BPD, as well as in euthymic periods. The percentage of BPD patients with cognitive impairment (CIBD) varies among studies, with 40-60% representing the best estimate. ...

Phase

Rapid Antidepressant Effects of Leucine

This is a pilot phase II clinical trial of L-leucine to test its efficacy in reducing depressive symptoms in MDD patients, especially those who exhibit increased inflammation. The determination of increased inflammation will be done post-hoc. During the screening visit, all study participants will provide demographic information and complete self-report ...

Phase