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Esophageal Cancer Clinical Trials

A listing of Esophageal Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (57) clinical trials

Identifying Genetic Markers for Esophageal Cancer and Stomach Cancer in Chinese Populations

OBJECTIVES: - Examine the role of genetics in the etiology and prevention of esophageal and gastric cancer in Chinese populations. - Identify potential early genetic markers of susceptibility for esophageal and gastric cancer. OUTLINE: - Tumor/nontumor study: Patients complete a 1-hour questionnaire about their general background, medical history, family history ...

Phase N/A

Erlotinib in Treating Patients With Barrett Esophagus

OBJECTIVES: Primary - To determine if erlotinib hydrochloride can be used as a chemopreventive agent that can cause histologic regression of Barrett esophagus in patients at high risk of developing esophageal cancer associated with high-grade dysplasia. Secondary - To assess whether erlotinib hydrochloride can cause molecular alterations in EGFR, phospho-EGFR, ...

Phase

Barrett's Esophagus Related Neoplasia (BERN) Project

B. BACKGROUND AND SIGNIFICANCE Burden of disease Barrett's esophagus (BE) is an acquired condition resulting from chronic gastroesophageal reflux disease and is a well recognized pre-malignant condition for the development of esophageal adenocarcinoma (EAC) (1, 2). BE is defined as the displacement of the squamocolumnar junction proximal to the gastroesophageal ...

Phase N/A

Biological Factors in Predicting Response to Treatment in Patients With Esophageal Cancer or Rectal Cancer

OBJECTIVES: Primary - Analyze various biological factors that can be used as markers to predict response to treatment and correlate with the signaling pathway of EGFR. Secondary - Establish a tissue bank to store information about the response to treatment and survival. OUTLINE: Patients undergo endoscopy, 11 biopsies of tumor ...

Phase N/A

Endoesophageal Cryotherapy For Ablating Barrett's Esophagus and Early Stage Esophageal Cancer

Baseline evaluation will include the following ( all are considered standard of care except # 8 ): 1. Informed consent. 2. Evaluation of inclusion/exclusion criteria 3. Demographics- date of birth, age, gender, ethnicity 4. Medical history and physical exam 5. Imaging (groups 2, 3 and 4) i. CT scan of ...

Phase

Combination of Chemoradiation Therapy and Epitope Peptide Vaccine Therapy in Treating Patients With Esophageal Cancer

Up-regulated ling cancer 10 (URLC10), TTK protein kinase (TTK) and K homology domain containing protein over expressed in cancer (KOC1) were identified as new targets of tumor associated antigens using cDNA microarray technologies combined with the expression profiles of normal and cancer tissues. Furthermore, anti-angiogenic therapy is now considered to ...

Phase

S-1 Cisplatin and Radiation Therapy in Treating Patients With Stage IIA Stage III or Stage IVA Esophageal Cancer That Can Be Removed by Surgery

OBJECTIVES: Primary - To evaluate response rate in patients with stage IIA-IVA resectable esophageal cancer treated with chemoradiotherapy comprising S-1, cisplatin, and radiotherapy. Secondary - To evaluate overall survival of these patients. - To evaluate progression-free survival of these patients. - To evaluate toxicity in these patients. - To correlate ...

Phase

Phase / Study of URLC10-177 and TTK-567 Peptide Vaccine Combined With CpG7909 in Patients With Esophageal Cancer

phase I: Patients will be vaccinated on day 1,8,15 and 22 of each 28-day treatment cycles. On each vaccination day, the URLC10-117 peptide(1mg) and TTK-567 peptide(1mg) mixed with CpG 7909 (escalating doses: 0, 0.02, 0.1mg/kg) emulsified with Montanide ISA 51 will be administered by subcutaneous injection. Repeated cycles of vaccine ...

Phase

Concurrent Chemoradiotherapy Containing Paclitaxel&Cisplatin With/Without Tarceva in Locally Advanced Esophageal Cancer

For the esophageal carcinoma in II~III stage, routine dosage of Paclitaxel and platinum medicine chemotherapy concurrently radical radiotherapy is worthy to be studied. On this base, we advanced approach the enlarged field radiotherapy and the intervention of Tarceva. And we approach the therapeutic effect for this method theoretically, which may ...

Phase

Study of Genes and Environment in Patients With Cancer in East Anglia Trent or West Midlands Regions of the United Kingdom

OBJECTIVES: - To obtain epidemiological information and biological material on a population-based series of cancer cases, including malignant melanoma, lymphoma, bladder, kidney, esophageal, and pancreatic cancer, and brain tumors. - Identify novel cancer susceptibility genes, by comparison of genotype frequencies in cases with the corresponding frequencies in large control series. ...

Phase N/A