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Head and Neck Cancer Clinical Trials

A listing of Head and Neck Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (201) clinical trials

Surgery and Radiation Therapy With or Without Interleukin-2 in Treating Patients With Cancer of the Mouth or Oropharynx

OBJECTIVES: - Compare the disease-free and overall survival in patients with previously untreated squamous cell carcinoma of the oral cavity or oropharynx treated with resection with or without and neoadjuvant and adjuvant perilymphatic interleukin-2 (IL-2) and radiotherapy. - Compare the response rate in patients treated with these regimens. - Determine ...


Genetic and Clinical Study of Patients With Xeroderma Pigmentosum Cockayne Syndrome or Trichothiodystrophy

OBJECTIVES: - Identify patients or confirm suspected cases of xeroderma pigmentosum (XP), Cockayne syndrome (CS), XP/CS, or trichothiodystrophy (TTD). - Document presence or absence of cancers (skin, eye, tongue, or internal) in these patients. - Document atypical features or unusual environmental exposures of these patients. - Examine tissue (skin, blood, ...

Phase N/A

Patient Evaluation for Head and Neck Surgery Branch Studies

This protocol will provide a means for screening potential candidates for head and neck surgery branch protocols. No investigational treatments will be administered in this protocol. The PI may, however, approve a patient who has been determined to be ineligible for HNSB protocols to undergo standard treatment because they present ...

Phase N/A

Cancer in Inherited Bone Marrow Failure Syndromes

Background: A prospective cohort of Inherited Bone Marrow Failure Syndrome (IBMFS) will provide new information regarding cancer rates and types in these disorders. Mutations in IBMFS genes are relevant to carcinogenesis in sporadic cancers. Patients with IBMFS who develop cancer differ in their genetic and/or environmental features from patients with ...

Phase N/A

Screening Trial to Study Eligibility of Patients to Participate in Head and Neck Surgery Clinical Trials

OBJECTIVES: - Evaluate eligibility of patients with neoplastic disease of the head and neck for clinical research protocols at the National Institute on Deafness and Other Communication Disorders Head and Neck Surgery Branch and National Cancer Institute. OUTLINE: Patients undergo various diagnostic procedures and clinical testing to determine protocol eligibility. ...

Phase N/A

Pre-habilitation of Patients With Head and Neck Cancer

Although the potential negative impact of head and neck cancer (HNC) and its treatment on eating ability and quality of life is well documented there is no evidence based and standardized rehabilitation program available for Danish patients affected by HNC while going through radiotherapy (with or without concurrent chemotherapy). This ...

Phase N/A

Electrochemotherapy on Head and Neck Cancer

Electric pulses may be used to transiently permeabilise cell membranes, enabling passage of otherwise non-permeating molecules. This dramatically enhances the cytotoxic effect of certain chemotherapeutic agents, and is termed electrochemotherapy. Electrochemotherapy is now standardly used in the treatment of cutaneous metastases of various cancers in over 100 cancer centers around ...


Safety Study of Afatinib and Postoperative Radiation Therapy to Treat Head and Neck Cancer

If you are willing to take part in this study you will be asked to undergo some screening tests and procedures to confirm your eligibility. Many of these tests and procedures are likely to be part of regular cancer care and may be done even if you do not take ...


Reliability and Validity of Patient Reported Outcome Measures in Head and Neck Cancer

This study is a cross-sectional, questionnaire-based psychometric study. The purpose of the study is to: (1) use Rasch methodology to assess the reliability, construct validity, and overall appropriateness of test score interpretation of 5 shoulder-related patient reported outcome measures in patients experiencing shoulder dysfunction following neck dissection surgery for head ...

Phase N/A

A Study of Prexasertib (LY2606368) With Chemotherapy and Radiation in Participants With Head and Neck Cancer

The primary purpose of Parts A and B of this study is to determine a recommended dose level of prexasertib (an inhibitor of checkpoint kinase 1[Chk-1]) in combination with cisplatin and radiation therapy (Part A) or cetuximab and radiation therapy (Part B) in participants with locally advanced head and neck ...