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Head and Neck Cancer Clinical Trials

A listing of Head and Neck Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (210) clinical trials

People with oral mucositis and head and neck cancer are asked to participate in a research study being conducted by Montefiore Medical Center.

Phase N/A

Metronomic Chemotherapy With Tegafur/Uracil for Head and Neck Squamous Cell Carcinoma

Head and neck squamous cell carcinoma (HNSCC) (excluding nasopharyngeal cancer) accounts for 4% to 5% of the cancer incidence in Taiwan.1 Localized disease is curable by surgery and irradiation. Two-thirds of patients present with advanced stages of the disease (stage III and IV), and are treated with multimodality therapy, including ...


Xerostomia Pilot Fudan: Acupuncture for Prevention of Radiation-Induced Xerostomia

Acupuncture is the use of very thin needles that are stuck in your skin at certain areas of the body, acupuncture is believed to affect bodily function. Screening Tests: Signing this consent form does not mean that you will be able to take part in this study. You will have ...

Phase N/A

p53 Gene Therapy for Head and Neck Malignant Tumors in Advanced Stage

Primary objectives of this study is to determine the efficacy profiles of rAd-p53 intra-tumor injection alone, with concurrent chemotherapy, with concurrent radiotherapy, or combination with surgery for treatment of head and neck malignant tumors in advanced stage (stage III or IV) including target lesion complete response rate (LCR) and overall ...


Functional MRI in Finding Hypoxia in Patients Undergoing Chemotherapy and Radiation Therapy for Stage III or Stage IV Head and Neck Cancer

OBJECTIVES: - Determine the undertaken oxygen sensitive MRI for the detection of hypoxia in patients with Stage III-IV head and neck cancer. - Correlate MRI parameters with histology, gene expression, and plasma osteopontin. - Correlate tumor hypoxia measurements with patient prognosis and treatment response. OUTLINE: - Pre-therapy MRI: Patients undergo ...


DNA Analysis of Tumor Tissue Samples From Patients With Human Papilloma Virus-Associated Cancer of the Oropharynx

OBJECTIVES: - Analyze PIK3CA expression and mutation and p110α amplification and expression in tumor tissue samples from patients with human papilloma virus positive (HPV+) and human papilloma virus negative (HPV-) squamous cell carcinoma (SCC) of the oropharynx. - Determine proliferation and survival after PI3K inhibition in HPV(+) and HPV(-) oropharyngeal ...

Phase N/A

Markers for Cancer in Families at High Risk of Nasopharyngeal Cancer

OBJECTIVES: - Evaluate the clinical utility of serum Epstein-Barr virus antibody testing for the identification of individuals at increased risk of nasopharyngeal carcinoma (NPC) within high-risk NPC multiplex families. OUTLINE: Participants undergo ear, nose, and throat examination (i.e., collection of blood, saliva, nasopharyngeal tissue, and urine and undergo a nasopharyngeal ...

Phase N/A

Tissue Sample Collection From Patients With Head and Neck Cancer and From Healthy Participants

OBJECTIVES: - Maintain and update a clinical database pertaining to diagnosis and treatment outcome of patients with head and neck cancer. - Develop a repository of biospecimens from these patients. OUTLINE: Tumor tissue samples and/or bronchial washings are collected from patients undergoing planned surgery and/or bronchoscopy, respectively. Buccal swabs and/or ...

Phase N/A

Biomarkers in Tissue Samples From Patients Who Have Undergone Neck Dissection for Oral Cancer

OBJECTIVES: - To test preliminary data from node-positive oral squamous cell carcinoma (OSCC) signatures for their ability to predict lymph-positive primaries using a cohort of OSCC tumors. - To perform lymph node prediction using sentinel lymph node-biopsied primaries. - To validate the preliminary data node-positive OSCC signature and test its ...

Phase N/A