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Head and Neck Cancer Clinical Trials

A listing of Head and Neck Cancer medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (33) clinical trials

DNA Analysis of Tumor Tissue Samples From Patients With Human Papilloma Virus-Associated Cancer of the Oropharynx

OBJECTIVES: - Analyze PIK3CA expression and mutation and p110α amplification and expression in tumor tissue samples from patients with human papilloma virus positive (HPV+) and human papilloma virus negative (HPV-) squamous cell carcinoma (SCC) of the oropharynx. - Determine proliferation and survival after PI3K inhibition in HPV(+) and HPV(-) oropharyngeal ...

Phase N/A

Markers for Cancer in Families at High Risk of Nasopharyngeal Cancer

OBJECTIVES: - Evaluate the clinical utility of serum Epstein-Barr virus antibody testing for the identification of individuals at increased risk of nasopharyngeal carcinoma (NPC) within high-risk NPC multiplex families. OUTLINE: Participants undergo ear, nose, and throat examination (i.e., collection of blood, saliva, nasopharyngeal tissue, and urine and undergo a nasopharyngeal ...

Phase N/A

Tissue Sample Collection From Patients With Head and Neck Cancer and From Healthy Participants

OBJECTIVES: - Maintain and update a clinical database pertaining to diagnosis and treatment outcome of patients with head and neck cancer. - Develop a repository of biospecimens from these patients. OUTLINE: Tumor tissue samples and/or bronchial washings are collected from patients undergoing planned surgery and/or bronchoscopy, respectively. Buccal swabs and/or ...

Phase N/A

Biomarkers in Tissue Samples From Patients Who Have Undergone Neck Dissection for Oral Cancer

OBJECTIVES: - To test preliminary data from node-positive oral squamous cell carcinoma (OSCC) signatures for their ability to predict lymph-positive primaries using a cohort of OSCC tumors. - To perform lymph node prediction using sentinel lymph node-biopsied primaries. - To validate the preliminary data node-positive OSCC signature and test its ...

Phase N/A

Biomarkers in Patients With Head and Neck Cancer and in Healthy Volunteers

OBJECTIVES: - Correlate the differences in serum protein profiles with the differences in the number of peptide matches in patients with squamous cell carcinoma of the head and neck and in healthy volunteers. - Correlate protein levels with the largest difference in peptide matches in sera in these participants. OUTLINE: ...

Phase N/A

Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer Head and Neck Cancer or Aerodigestive Tract Cancer and in Normal Volunteers

OBJECTIVES: Primary - Determine intermediate biomarkers of premalignant respiratory epithelial lesions, such as genetic mutations or altered growth factor expression, in patients with dysplasia of the respiratory epithelium or lung cancer, head and neck cancer, or aerodigestive tract cancer. Secondary - Establish a tissue repository of normal and dysplastic respiratory ...

Phase N/A

Studies on Tumors of the Thyroid

The purpose of this study is to evaluate methods for preoperative diagnosis and therapy of thyroid cancer and to screen patients for participation in other protocols. Study subjects will include adults and children with thyroid nodules or cancer requiring diagnostic fine needle aspiration biopsy, surgery, radioiodine scanning or therapy for ...

Phase N/A

Genetic and Clinical Study of Patients With Xeroderma Pigmentosum Cockayne Syndrome or Trichothiodystrophy

OBJECTIVES: - Identify patients or confirm suspected cases of xeroderma pigmentosum (XP), Cockayne syndrome (CS), XP/CS, or trichothiodystrophy (TTD). - Document presence or absence of cancers (skin, eye, tongue, or internal) in these patients. - Document atypical features or unusual environmental exposures of these patients. - Examine tissue (skin, blood, ...

Phase N/A

Patient Evaluation for Head and Neck Surgery Branch Studies

This protocol will provide a means for screening potential candidates for head and neck surgery branch protocols. No investigational treatments will be administered in this protocol. The PI may, however, approve a patient who has been determined to be ineligible for HNSB protocols to undergo standard treatment because they present ...

Phase N/A

Cancer in Inherited Bone Marrow Failure Syndromes

Background: A prospective cohort of Inherited Bone Marrow Failure Syndrome (IBMFS) will provide new information regarding cancer rates and types in these disorders. Mutations in IBMFS genes are relevant to carcinogenesis in sporadic cancers. Patients with IBMFS who develop cancer differ in their genetic and/or environmental features from patients with ...

Phase N/A