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Amyotrophic Lateral Sclerosis (ALS) Clinical Trials

A listing of Amyotrophic Lateral Sclerosis (ALS) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.


Found (104) clinical trials

Muscular Biomarkers in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS), the most common MND, is a fatal adult-onset neuromuscular disease. Due to clinical heterogeneity and absence of biological tools to diagnose ALS, the delay between the first symptoms and diagnosis averages 9-13 months. A group of pathophysiological processes, including oxidative stress and glutamate-mediated excitotoxicity contribute to ...

Phase N/A

Amyotrophic Lateral Sclerosis and the Innate Immune System

Amyotrophic lateral sclerosis (ALS) is a progressive, deadly, neurodegenerative disease which affects the upper and lower motor neurons. This leads to profound muscular dystrophy, hyperreflexia, fasciculations and paresis of the bulbar as well as the skeletal musculature. ALS causes increasing physical fatigue and the patients soon become bedridden and respiratory ...

Phase N/A

ALS Testing Through Home-based Outcome Measures

ALS AT HOME is a single-center study of up to 250 participants being done to determine the extent to which frequent sampling can improve the qualities of outcome measures collected at home by study participants. The objectives of this study are to assess the extent to which frequent sampling can ...

Phase N/A

CNS10-NPC-GDNF for the Treatment of ALS

This study will be the first to use a genetically modified progenitor cells to treat a neurodegenerative disease. This is a Phase 1/2a, single-center, blinded (as to side of injection), safety study of two escalating doses of human neural progenitor cells expressing GDNF (CNS10-NPC-GDNF) delivered unilaterally to the lumbar region ...


Trial of Amivita in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting upper and lower motor neurons. Survival is typically 2 to 5 years from symptom onset; death is usually from respiratory paralysis. Standard therapy is with Riluzole 100 mg/day, a FDA approved treatment for ALS that has a small effect on ...

Phase N/A

Laughter Therapy Effects on Mood Stress and Self-efficacy in People With Neurological Diseases.

Laughter therapy (LT) has potential benefits in treating illness. It combines laughter with breathing and body exercises to stimulate laughter, both real and artificial, in a group setting. Laughter therapy may help treating illness by strengthening breathing muscles, improving mood, and providing pain and stress relief. EvergreenHealth has presented laughter ...

Phase N/A

Study of Two Intrathecal Doses of Autologous Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis

The study is an open-label, unmasked, uncontrolled phase I and II trial to evaluate safety and efficacy of two injections of autologous mesenchymal stem cells (MSC) in Amyotrophic Lateral Sclerosis (ALS) patients. Patients will be recruited trough a web-based registration system, open for all ALS Brazilian patients. The patients will ...


Respiratory Strength Training in Persons With Amyotrophic Lateral Sclerosis (ALS)

This research study will measure the maximum inspiratory and expiratory pressure with secondary measures of respiration, swallow, cough, quality of life and global disease progression following twelve-weeks of treatment compared to the sham group. As a participant two evaluations at the University of Florida Swallowing Systems Core laboratory located at ...

Phase N/A

The Use of Airway Clearance Devices in ALS

This 180 day (25.7 weeks) pilot study is designed to evaluate the effectiveness of airway clearance devices in adults with ALS. Subjects will be randomized in a 1:1 ratio to one of two treatment groups: treatment with a mechanical HCFF device alone or treatment with both a mechanical HFCC device ...

Phase N/A

Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS

Application - HUM00107546 Study Title: Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS Full Study Title: Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS If there are other U-M studies related to this project, enter the eResearch ID number (HUM#) or IRBMED Legacy study ...

Phase N/A