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Amyotrophic Lateral Sclerosis (ALS) Clinical Trials

A listing of Amyotrophic Lateral Sclerosis (ALS) medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (106) clinical trials

Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis (ALS) is a rare disease with a worldwide incidence of 2-3 cases per 100,000 individuals/year and it is characterized by progressive neurodegeneration of motor neurons. When motor neurons degenerate the ability of the brain to initiate and control muscle movement is lost. ALS manifests in two forms: ...

Phase N/A

Innovative Ultrasound Technology in Neuromuscular Disease

This study is utilizing ultrasound measurement to measure neuromuscular disease status in adult patients. The hypothesis is the by quantifying ultrasound data, it is possible that ultrasound can be utilized as a tool to determine if a disease is responding to therapy or progressing.

Phase N/A

Imaging and BioFluid Biomarkers in Amyotrophic Lateral Sclerosis

In this trial, approximately 200 subjects will participate in this study from 2 Northeast ALS Consortium (NEALS) centers in the United States. Fifty (50) ALS participants will be age and gender matched to 50 participants with no known neurological disorder (healthy controls). Of these, twenty five (25) ALS participants will ...

Phase N/A

Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders

Speech and swallowing abnormalities are important symptoms associated with disorders of the central nervous system, motor neuron disease (such as amyotrophic lateral sclerosis), myasthenia gravis, and primary muscle conditions. In addition to characterizing the evolution in muscle architecture that could underlie associated orofacial weakness, identifying new ways to measure these ...

Phase N/A

SOD1 Kinetics Measurements in ALS Patients

Background: Novel targeted therapeutic strategies are being developed for genetic subsets of ALS, such as those caused by dominantly inherited mutations in the superoxide dismutase 1 gene (SOD1). Investigators have developed an antisense oligonucleotide (ASO) inhibitor of SOD1 biosynthesis for ALS patients who carry mutations in SOD1. This ASO is ...

Phase N/A

Predictive Factors for the Diagnosis of Early Noninvasive Ventilation Equipment

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. The diagnosis of this diaphragmatic dysfunction in the ALS subject is done all too often on the occasion of a hospitalization for acute respiratory insufficiency, which aggravates then the prognosis of the patients. The presence of these factors at ...

Phase N/A

Non-invasive Brain Stimulation for the Treatment of Depression Symptoms in ALS: A Pilot Study

The objective of this study is to evaluate the role of repetitive transcranial magnetic stimulation (rTMS) for symptom reduction of depression and cognitive loss among patients with Amyotrophic Lateral Sclerosis (ALS) and other Neurodegenerative Diseases. Behavioral symptoms in ALS have been under scrutiny since its earliest descriptions, nearly 30 years ...

Phase N/A

Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS

Application - HUM00107546 Study Title: Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS Full Study Title: Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS If there are other U-M studies related to this project, enter the eResearch ID number (HUM#) or IRBMED Legacy study ...

Phase N/A

Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS

Most neurological injuries such as spinal cord injuries (SCI) and amyotrophic lateral sclerosis (ALS) spare a portion of nerve circuitry. Strengthening spared nerve circuits represents a critical method to improve functional recovery. Different forms of magnetic and electrical stimulation have been used to activate brain, spinal cord, nerve, or muscle ...

Phase N/A

The National Amyotrophic Lateral Sclerosis Registry

The purpose of this registry is to (A) better describe the incidence and prevalence of Amyotrophic Lateral Sclerosis (ALS) in the United States;(B) examine appropriate factors, such as environmental and occupational, that may be associated with the disease; (C) better outline key demographic factors (such as age, race or ethnicity, ...

Phase N/A