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Alzheimer's Disease Clinical Trials

A listing of Alzheimer's Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (34) clinical trials

This study will evaluate the safety and efficacy of NPT088 or Placebo in participants with probable Alzheimer's Disease

Phase

If you qualify, the study may involve 3 screening visits, 1 separate in-clinic stay of 5 days/4 nights and 10 outpatient visits. All study exams and procedures are provided at no cost to you. You do not need medical insurance to participate.

Phase

Patient Inclusion Criteria: Ages: over 55-90 Male/Female 12 Month Long Clinical Trial MMSE score 24-30/20-26 Subjects must meet criteria for Prodromal AD or Mild AD: Mini Mental State Examination (MMSE) score between 20-30 Clinical Dementia Rating Scale (CDR) score of 0.5 or 1 a free recall score of lesser or ...

Phase

The objective of this study is to assess the safety and tolerability of the study drug given orally twice daily for 28 days. The study will also assess the effects of study drug on oral and cerebrospinal fluid biomarkers. The study evaluations include 2 detailed dental examinations and 2 lumbar ...

Phase

The rrAD study is testing several strategies that may reduce the risk of Alzheimer’s disease in individuals at risk for the disease when compared to usual care. These strategies include: Aerobic exercise Intensive medical management of blood pressure and cholesterol The combination of these two approaches

Phase

A Study to Investigate the Regional Brain Kinetics of Brain Drug Transporters Using P-glycoprotein and Breast Cancer Resistance Protein Substrates and by Using the Positron Emission Tomography Ligand 11C-JNJ-63779586 in the Human Brain

The purpose of this study is to investigate the total body biodistribution and radiation dosimetry of 11C-JNJ-63779586 by Positron Emission Tomography (PET) in healthy young adult males (Part A); to estimate and compare the uptake, distribution, and clearance of 11C-JNJ-63779586 in the brain by PET between mild Alzheimer Disease (AD) ...

Phase

Salsalate in Patients Mild to Moderate Alzheimer's Disease

This is a Phase 1b, 12-month, randomized, double-blind, placebo-controlled study of the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of salsalate in patients with mild to moderate AD. Approximately 40 subjects will be randomized 1:1 to placebo or active. All study drugs will be administered orally bid [two placebo tablets ...

Phase

Prediction of Cognitive Properties of Memantine for Neurodegenerative Diseases

The aim of the present study is to test the effect of a 15-day treatment with memantine on a mixed battery associating cognitive assessment, imaging and neurophysiological tests in healthy volunteers. This multicenter, randomized, placebo-controlled, cross-over study is double-blind controlled and is conducted in 3 centers located in France (Lille, ...

Phase

Combined Subthalamic and Nucleus Basalis Meynert Deep Brain Stimulation for Parkinson's Disease With Dementia

Combined subthalamic and Nucleus basalis Meynert Deep Brain Stimulation for Parkinson's disease with dementia DEMPARK-DBS STUDY Indication: Parkinson's disease with mild to moderate dementia Primary Objective: To provide a proof of safety of combined bilateral subthalamic nucleus (STN) and basal nucleus of Meynert (NBM) stimulation in treating levodopa responsive motor ...

Phase

Safety Tolerability and Pharmacokinetics of DKF-310 ( (Donepezil).

This is a study to evaluate safety, tolerability and PK of DKF-310 IM injection in healthy male volunteers.

Phase