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Alzheimer's Disease Clinical Trials

A listing of Alzheimer's Disease medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.

RESULTS

Found (23) clinical trials

Dominantly Inherited Alzheimer Network (DIAN)

Dominantly inherited Alzheimer's disease (AD) represents less than 1% of all cases of AD and is an important model for study because the responsible mutations have known biochemical consequences that are believed to underlie the pathological basis of the disorder. Three major hypotheses will be tested: - First, that there ...

Phase N/A

Copy Number Variations Inflammatory Cytokines and the Risk of Dementia

This is a hospital-based case-control study. We plan to assess the association of CNV and inflammatory cytokine with the risk of dementia. Hopefully to find some genetic biomarkers to identify the risk of dementia at an early stage.

Phase N/A

Implications of Amyloid Pathology

There is compelling evidence supporting amyloid as one of the key pathologic agents in AD. Autopsy studies suggest the amount and location of fibrillar amyloid deposition does not relate strongly to the degree and type of clinical impairment, compared to tau pathology and neuronal loss. A substantial percentage of individuals ...

Phase N/A

Evolution of Memory Related Activity

The development of biomarkers is now especially critical, as there are a number of promising disease-modifying therapies entering early phase clinical trials, with additional novel therapeutic strategies in development. It is essential to develop biomarkers that can detect a "signal of efficacy" over a relatively short time frame for use ...

Phase N/A

Smart Environment Technology for Longitudinal Behavior Analysis and Intervention

By tracking residents' daily behavior over a long period of time our intelligent software can perform automated functional assessment and identify trends that are indicators of acute health changes and slower progressive decline (e.g., dementia). By implementing prompt-based interventions that support functional independence and promote healthy lifestyle behaviors (e.g., social ...

Phase N/A

Alzheimer's Disease Genetics Study

The purpose of the Alzheimer's Disease Genetics Study is to help identify the genes that may be responsible for causing Alzheimer's Disease (AD) by collecting genetic material from families with multiple members diagnosed with AD. Qualifying families will have two living blood-related individuals who have been diagnosed with or are ...

Phase N/A

Predictors of Cognitive Decline in Normal Aging

Studies of normal aging and mild cognitive impairment (MCI) show that loss of neurons and reduction in size of the hippocampal part of the brain predict a person's conversion from MCI to Alzheimer's disease (AD). Increases in tangle-related abnormal tau proteins, specifically P-tau231, also appear to be related. This study ...

Phase N/A

Biomarkers and Early Alzheimer's Disease

The goal of this project is to use magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) biomarkers to identify cognitively normal participants who show the earliest clinically detectable brain changes of Alzheimer's disease (AD). The major hypothesis for this study is that CSF P-tau231 measurement improves the accuracy of MRI ...

Phase N/A

A Study of Why People With Early Memory Problems Fall or Almost Fall

The specific objectives of this six month study are to: characterize falls and near-falls in community dwelling older adults with early-stage dementia; determine which potentially modifiable physical fall risk factors contribute to falls and near-falls in older adults with early-stage dementia; examine the relationship between dementia sub-type, medical and neuropsychological ...

Phase N/A