Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity

Last updated: April 20, 2026
Sponsor: Metsera, a wholly owned subsidiary of Pfizer
Overall Status: Active - Recruiting

Phase

3

Condition

Obesity

Diabetes Prevention

Hypertriglyceridemia

Treatment

MET097

Placebo

Clinical Study ID

NCT07311850
VESPER-4 (MET097-25-301)
  • Ages 18-99
  • All Genders

Study Summary

This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks. The primary endpoint will be assessed after 64 weeks of treatment with the secondary at 84 weeks.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • BMI ≥ 30 kg/m2 or BMI ≥ 27.0 kg/m2 to <30.0 kg/m2 and presence of at least 1 of thefollowing weight- related comorbidities: Hypertension, dyslipidemia, obstructivesleep apnea, or cardiovascular disease)

Exclusion

Exclusion Criteria:

  • Have any form of diabetes

  • Have a self-reported body weight change > 5 kg (11 pounds) within 3 months prior toScreening

  • Personal or family history of medullary thyroid carcinoma (MTC) or multipleendocrine neoplasia syndrome type 2 (MEN-2)

  • History of chronic pancreatitis or presence of acute pancreatitis within the past 180 days prior to the Screening visit; or active/current, symptomatic gallbladderdisease

Study Design

Total Participants: 3500
Treatment Group(s): 2
Primary Treatment: MET097
Phase: 3
Study Start date:
December 29, 2025
Estimated Completion Date:
May 31, 2028

Connect with a study center

  • CEDIC

    Buenos Aires, C1060
    Argentina

    Site Not Available

  • CINME

    Buenos Aires, C1056ABI
    Argentina

    Site Not Available

  • Centro Medico Viamonte

    Buenos Aires, C1120AAC
    Argentina

    Site Not Available

  • CIDIM

    Córdoba, X5000AVE
    Argentina

    Site Not Available

  • Clinica Privada Velez Sarsfield

    Córdoba, 5000
    Argentina

    Site Not Available

  • Instituto de Investigaciones Clinicas Cordoba

    Córdoba, X5000AAW
    Argentina

    Site Not Available

  • CIPADI - Centro Integral de Prevencion Y Atencion en Diabetes

    Godoy Cruz, M5501ARP
    Argentina

    Site Not Available

  • IIC Mar del Plata

    Mar del Plata, 7600
    Argentina

    Site Not Available

  • CIAD Moron

    Morón, B1708EPE
    Argentina

    Site Not Available

  • Centro Medico Privado de Reumatologia

    San Miguel de Tucumán, T4000AXA
    Argentina

    Site Not Available

  • Instituto Medico Catamarca (IMEC)

    Santa Fe, S2000
    Argentina

    Site Not Available

  • MHAT Botevgrad

    Botevgrad, 2140
    Bulgaria

    Site Not Available

  • 4 Life EOOD

    Burgas, 8018
    Bulgaria

    Site Not Available

  • Multiprofile Hospital for Active Treatment Dobrich AD (MHAT Dobrich AD)

    Dobrich, 9300
    Bulgaria

    Site Not Available

  • Medical Center New Polyclinic Gabrovo Ltd.

    Gabrovo, 5300
    Bulgaria

    Site Not Available

  • Medical Center Zdrave 1

    Kozloduy, 3320
    Bulgaria

    Site Not Available

  • FutureMeds Plovdiv

    Plovdiv, 4000
    Bulgaria

    Site Not Available

  • MHAT Sveta Karidad EAD

    Plovdiv, 4004
    Bulgaria

    Site Not Available

  • Diagnostic Consultative Center Aleksandrovska

    Sofia, 1431
    Bulgaria

    Site Not Available

  • Medical Center Hera EOOD

    Sofia, 1710
    Bulgaria

    Site Not Available

  • Prevencia - 2000 - Medical Center for Prehospital Medical Care OOD

    Stara Zagora, 6000
    Bulgaria

    Site Not Available

  • UMHAT "Prof. Dr. Stoyan Kirkovich"AD

    Stara Zagora, 6003
    Bulgaria

    Site Not Available

  • MC Nova Clinic

    Varna, 9000
    Bulgaria

    Site Not Available

  • Medical Center - Clinic Nova

    Varna,
    Bulgaria

    Site Not Available

  • Medical Centre Pratia Clinic EOOD

    Varna, 9020
    Bulgaria

    Site Not Available

  • MC Nevromedics Ltd.

    Veliko Tarnovo, 5005
    Bulgaria

    Site Not Available

  • Medical Center Berbatov

    Yambol, 8600
    Bulgaria

    Site Not Available

  • C-health Research

    Edmonton, Alberta T6H 2L4
    Canada

    Site Not Available

  • Synergy Medical Clinic

    Sherwood Park, Alberta T8H 0N2
    Canada

    Site Not Available

  • Centricity Research Etobicoke Endocrinology

    Etobicoke, Ontario M9R 4E1
    Canada

    Site Not Available

  • The Wharton Medical Clinic Clinical Trials Inc

    Hamilton, Ontario L8L 5G8
    Canada

    Site Not Available

  • LMC Diabetes & Endocrinology - Bayview (Centricity Research Toronto LMC Multispecialty)

    Toronto, Ontario M4G 3E8
    Canada

    Site Not Available

  • Manna Research Mirabel

    Mirabel, Quebec J7J 2K8
    Canada

    Site Not Available

  • Pratia Brno,s.r.o

    Brno, 60200
    Czechia

    Site Not Available

  • Nemocnice Jihlava

    Jihlava, 58601
    Czechia

    Site Not Available

  • Edumed s.r.o.

    Náchod, 54701
    Czechia

    Site Not Available

  • Agentura science pro s.r.o.

    Olomouc, 77900
    Czechia

    Site Not Available

  • PreventaMed s.r.o.

    Olomouc, 77900
    Czechia

    Site Not Available

  • CCR Ostrava

    Ostrava, 702 00
    Czechia

    Site Not Available

  • Pratia Pardubice

    Pardubice, 53002
    Czechia

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  • Fakultní nemocnice Královské Vinohrady

    Prague, 100 34
    Czechia

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    Prague, 18100
    Czechia

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    Prague, 120 00
    Czechia

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  • CDG Studienambulanz Hartard

    Munich, Bavaria 80809
    Germany

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  • Studienzentrum FMZ Radowsky

    Leipzig, Saxony 4179
    Germany

    Site Not Available

  • Kardiologische Praxis Dr. med. univ. Wolfgang Jungmair

    Bad Homburg, 61348
    Germany

    Site Not Available

  • Diabetespraxis Dr. Braun

    Berlin, 13187
    Germany

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    Berlin, 10629
    Germany

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    Berlin, 10117
    Germany

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    Berlin, 12205
    Germany

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  • Pratia

    Dresden, 1069
    Germany

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  • Medizentrum Essen Borbeck

    Essen, 45355
    Germany

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  • Praxis am Markt - Dr. Bernd Becker

    Essen, 45355
    Germany

    Site Not Available

  • DZHW

    Hamburg, 22607
    Germany

    Site Not Available

  • Diabetes Studienzentrum Wilhelmsburg

    Hamburg, 21109
    Germany

    Site Not Available

  • Klinische Forschung Hamburg GmbH / Pratia

    Hamburg, 20253
    Germany

    Site Not Available

  • Praxis Reinfeld Mitte

    Holstein, 23858
    Germany

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  • Zentrum fuer klinische Forschung Koeln Duennwald

    Kaln, 51069
    Germany

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    Karlsruhe, 76137
    Germany

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  • AmBeNet GmbH

    Leipzig, 4107
    Germany

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    Münster, 48145
    Germany

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  • Gemeinschaftspraxis PD Dr. med. habil. Holger Kittner & Dr. Hartig

    Naunhof, 4683
    Germany

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    Offenbach, 63065
    Germany

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    Wangen, 88239
    Germany

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    Weinheim, 69469
    Germany

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  • Zdrowie Osteo Medic sc L i A Racewicz, A i J Supronik

    Bialystok, 15-351
    Poland

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    Bydgoszcz, 85-796
    Poland

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    Bydgoszcz, 85-231
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    Gdansk, 80-546
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    Gdansk, 80-382
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    Gdynia, 81-338
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    Gdynia, 81-384
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    Katowice, 40-081
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    Katowice, 40-040
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    Krakow, 31-501
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    Lodz, 90-338
    Poland

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    Lodz, 91-393
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    Lodz, 90-302
    Poland

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    Lodz, 90-127
    Poland

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    Lublin, 20-718
    Poland

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    Olsztyn, 10-165
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    Oświęcim, 32-600
    Poland

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    Piotrkow Trybunalski, 97-300
    Poland

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    Piotrkow Trybunalski, 97-300
    Poland

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  • Praktyka Lekarska Ewa Krzyzagorska

    Poznan, 61-655
    Poland

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    Poznan, 60-702
    Poland

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    Siedlce, 08-110
    Poland

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  • Metabolica Sp. z o.o., NZOZ METABOLICA Ośrodek Badań Klinicznych

    Tarnów, 33-100
    Poland

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  • Etg Warszawa

    Warsaw, 02-677
    Poland

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    Warsaw, 00-215
    Poland

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  • Instytut Diabetologii.sp.z.o.o.

    Warsaw, 02-117
    Poland

    Site Not Available

  • Synexus Polska Sp. z o.o., Oddzial w Warszawie

    Warsaw, 02-672
    Poland

    Site Not Available

  • FutureMeds Warszawa Targowek

    Warszawa Targowek, 03-291
    Poland

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  • FutureMeds Wroclaw

    Wroclaw, 53-673
    Poland

    Site Not Available

  • Synexus Polska Sp. z o.o., Oddział we Wrocławiu

    Wroclaw, 50-381
    Poland

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  • Minimed S.R.L.

    Bacau,
    Romania

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  • Futuremeds S.R.L., Brasov

    Brasov,
    Romania

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  • Fundatia Dr Victor Babes

    Bucharest, 30303
    Romania

    Site Not Available

  • Hightech Medical Services S.R.L (Centrul pentru Studiul Metabolismului)

    Bucharest, 011053
    Romania

    Site Not Available

  • Institutul Clinic Fundeni

    Bucharest,
    Romania

    Site Not Available

  • Institutul National de Endocrinologie "C.I. Parhon"

    Bucharest,
    Romania

    Site Not Available

  • Futuremeds S.R.L., Craiova

    Craiova,
    Romania

    Site Not Available

  • Futuremeds S.R.L., Galati

    Galati,
    Romania

    Site Not Available

  • Centru Medical "GRANDMED"

    Oradea,
    Romania

    Site Not Available

  • Sc Gensan Srl/Policlinica Astra

    Sibiu, 550371
    Romania

    Site Not Available

  • Centrul Medical Mediab - Mediab Srl

    Târgu Mureş,
    Romania

    Site Not Available

  • DIABEDA s.r.o.

    Bratislava, Bratislava
    Slovakia

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  • Medispektrum

    Bratislava, 85101
    Slovakia

    Site Not Available

  • Poliklinika Váš Lekár

    Bratislava - Ružinov, 91109
    Slovakia

    Site Not Available

  • Cardio D&R Košice

    Košice, 040 22
    Slovakia

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  • Medical group Kosice s.r.o.

    Košice, 04001
    Slovakia

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  • MEDI-DIA s.r.o.

    Prešov, 080 01
    Slovakia

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  • Tatratrial s.r.o.

    Rožňava, 048 01
    Slovakia

    Site Not Available

  • JAL s.r.o.

    Trnava, 91701
    Slovakia

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  • Medivasa sro

    Žilina, 01001
    Slovakia

    Site Not Available

  • Hospital Universitario Virgen de la Victoria

    Málaga, Málaga 29010
    Spain

    Site Not Available

  • Hospital Universitario Torrecárdenas (CPE Bola Azul)

    Almería, 04009
    Spain

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  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035
    Spain

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  • Hospital Vithas Sevilla

    Castilleja de la Cuesta, 41950
    Spain

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  • Futuremeds Spain Cadiz

    Chiclana de la Frontera, 11139
    Spain

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    Madrid, 28003
    Spain

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    Palma de Mallorca, 07120
    Spain

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  • Hospital Virgen del Camino

    Sanlúcar de Barrameda, 11540
    Spain

    Site Not Available

  • Futuremeds Spain Sevilla

    Seville, 41012
    Spain

    Site Not Available

  • Nuevas Tecnologías en Diabetes y Endocrinología S.L.

    Seville, 41003
    Spain

    Site Not Available

  • Ecg Médica S.L.

    Valencia, 46015
    Spain

    Site Not Available

  • Civia Health Sunderland

    Hendon, CITY of Sunderland SR1 1PB
    United Kingdom

    Site Not Available

  • Boots Peterborough

    Peterborough, Cambridgeshire PE1 1NW
    United Kingdom

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  • Bodyline Medical Clinic Warrington

    Warrington, Cheshire EAST WA1 3TZ
    United Kingdom

    Site Not Available

  • Boots Brighton

    Brighton, EAST Sussex BN1 2BE
    United Kingdom

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  • Bodyline Medical Clinic St Helens

    St Helens, Liverpool WA9 1AF
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    Openshaw, Manchester M11 1AA
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    Nottingham, Nottinghamshire NG1 3QS
    United Kingdom

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  • FutureMeds Glasgow McCafferty House

    Glasgow, Scotland G20 7BE
    United Kingdom

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    Bellshill, ML4 3NJ
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    Birmingham, B4 7TA
    United Kingdom

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    Birmingham, B21 9RY
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    Birmingham, B15 2 SQ
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  • Southmead Hospital

    Bristol, BS10 5NB
    United Kingdom

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  • FutureMeds Liverpool

    Bromborough, CH62 6EE
    United Kingdom

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  • Synexus/Trialmed Cardiff

    Cardiff, CF15 9SS
    United Kingdom

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  • Panthera Biopartners Limited - Enfield

    Enfield, EN3 4GS
    United Kingdom

    Site Not Available

  • Panthera Biopartners Limited - Glasgow

    Glasgow, G51 4TY
    United Kingdom

    Site Not Available

  • Bodyline Medical Clinic Crosby

    Liverpool, L224QQ
    United Kingdom

    Site Not Available

  • FutureMeds London

    London, NW10 2PB
    United Kingdom

    Site Not Available

  • Synexus/Trialmed Manchester

    Manchester, M15 6SE
    United Kingdom

    Site Not Available

  • Kiltearn Medical Centre

    Nantwich, CW5 5NX
    United Kingdom

    Site Not Available

  • FutureMeds Newcastle

    Newcastle upon Tyne, NE6 1SG
    United Kingdom

    Site Not Available

  • DANES Medical Centre

    Northampton, NN1 5PH
    United Kingdom

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  • Panthera Biopartners Limited - Preston

    Preston, PR2 9QB
    United Kingdom

    Site Not Available

  • Panthera Biopartners Limited - Rochdale

    Rochdale, OL11 4AU
    United Kingdom

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  • Clifton Medical Centre

    Rotherham, S65 2EN
    United Kingdom

    Site Not Available

  • Sandbach GPs

    Sandbach, CW11 1EQ
    United Kingdom

    Site Not Available

  • Panthera Biopartners Limited - Sheffield

    Sheffield, S2 5FX
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    Soham, ELY CB75JD
    United Kingdom

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    Stoke-on-Trent, ST1 5TL
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    Teeside, TS19 8PE
    United Kingdom

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    York, YO24 4LJ
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  • Headlands Research

    Scottsdale, Arizona 85260
    United States

    Active - Recruiting

  • Alliance Research Institute

    Canoga Park, California 91304
    United States

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  • Clinical Innovations, Inc dba CITrials

    Riverside, California 92506
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  • Peninsula Headlands LLC

    Rolling Hills, California 90274
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  • Collaborative Neuroscience Research, LLC

    Torrance, California 90504
    United States

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  • Research Site 97301-001007

    Riverside 5387877, California 5332921 92506
    United States

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    Torrance 5403022, California 5332921 90504
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    Englewood, Colorado 80113
    United States

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  • Research Site 97301-001077

    Englewood 5421250, Colorado 5417618 80113
    United States

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    Hollywood, Florida 33024
    United States

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  • Future Medical Research (Civia Health)

    Longwood, Florida 32750
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  • Advanced Clinical Research

    Miami, Florida 33156
    United States

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  • Oviedo Medical Research

    Oviedo, Florida 32765
    United States

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  • CenExel FCR - ForCare Clinical Research

    Tampa, Florida 33613
    United States

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  • Research Site 97302-001001

    Hollywood 4158928, Florida 4155751 33024
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  • DelRicht Research @ Springer Wellness and Restorative Health

    Atlanta, Georgia 30329
    United States

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  • CenExel iResearch, LLC

    Savannah, Georgia 31405
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  • CenExel CBH Health

    Gaithersburg, Maryland 20877
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  • Civia Health Shelby

    Shelby, Michigan 48315
    United States

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  • Clinical Research Professionals

    Chesterfield, Missouri 63005
    United States

    Active - Recruiting

  • Civia Health St. Louis

    Creve Coeur, Missouri 63141
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    Independence, Missouri 64055
    United States

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    Omaha, Nebraska 68114
    United States

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    Papillion, Nebraska 68046
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  • CenExel HRI - Hassman Research Institute

    Marlton, New Jersey 08053
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    Cary, North Carolina 27511
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  • Eximia EquiHealth Research

    Durham, North Carolina 27704
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    Wilmington, North Carolina 28403
    United States

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    Cary 4459467, North Carolina 4482348 27511
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    Portland, Oregon 97210
    United States

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    Greenville, South Carolina 29607
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    Spartanburg, South Carolina 29301
    United States

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  • Civia Health Goodlettsville

    Goodlettsville, Tennessee 37072
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    La Vergne, Tennessee 37086
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    Memphis, Tennessee 38117
    United States

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    Austin, Texas 78578
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    Dallas, Texas 75251
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    El Paso, Texas 79936
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    Richardson, Texas 75080
    United States

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    Bountiful, Utah 84010
    United States

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